Epstein J B, Page J L, Anderson G H, Spinelli J
Cancer Control Agency of British Columbia and Vancouver General Hospital, Canada.
Diagn Cytopathol. 1987 Sep;3(3):205-9. doi: 10.1002/dc.2840030306.
Laboratory techniques are often used to confirm a clinical diagnosis of oral herpes simplex virus (HSV) infection in patients with leukemia. In the present study, an immunoperoxidase technique (IPT) was used to examine smears taken from the oral mucosa of 44 patients with leukemia at Vancouver General Hospital. It was found that the IPT was as sensitive and specific as viral culture in confirming the presence of HSV. The IPT was found to be more predictive of symptomatic oral HSV disease than viral culture because it did not give positive results if there was only viral shedding in the absence of clinical disease. As the IPT is rapid and inexpensive as well as being specific, sensitive, and predictive, it has a definite role in the laboratory confirmation of oral HSV lesions in leukemics.
实验室技术常用于确诊白血病患者的口腔单纯疱疹病毒（HSV）感染。在本研究中，采用免疫过氧化物酶技术（IPT）对温哥华总医院44例白血病患者口腔黏膜涂片进行检测。结果发现，在确认HSV存在方面，IPT与病毒培养一样敏感和特异。研究发现，与病毒培养相比，IPT对有症状的口腔HSV疾病更具预测性，因为在没有临床疾病仅有病毒脱落的情况下，IPT不会给出阳性结果。由于IPT快速、廉价，且具有特异性、敏感性和预测性，它在白血病患者口腔HSV病变的实验室确诊中具有明确作用。
