Rauso Raffaele, Nicoletti Giovanni Francesco, Zerbinati Nicola, Lo Giudice Giorgio, Fragola Romolo, Tartaro Gianpaolo
Oral and Maxillofacial Surgery Unit, Multidisciplinary Department of Medical-Surgical and Dental Specialists, University of Campania "Luigi Vanvitelli", Naples, 80138, Italy.
Plastic Surgery Unit, Multidisciplinary Department of Medicine, Surgery and Odontological Sciences, "Luigi Vanvitelli" University Hospital, Naples, Italy.
Clin Cosmet Investig Dermatol. 2020 Oct 14;13:767-771. doi: 10.2147/CCID.S276959. eCollection 2020.
The purpose of the present study is to review published literature regarding complications following self-administration of hyaluronic acid (HA) filler. The following keywords were searched in Pubmed and Cochrane database: filler AND self injection, hyaluronic acid AND self injection; filler AND self administration; hyaluronic acid AND self administration. Two authors performed title and abstract eligibility assessment independently. Gray literature and all articles cited in the included papers were also screened and their reference lists were examined to identify other potentially pertinent studies. Non-English papers were excluded. A total of 4 complications following self injection of HA were identified. Conversely, after performing a general search through the Google Internet search engine, with the item "self-injection of hyaluronic acid filler", there were 604,000 hits. The number of articles reporting complications after the self administration of HA is few. Despite that internet searches on the same topic shows that self-administration of HA fillers is a widely discussed phenomenon in several on-line forums. The present review suggests that complications after self-injection of HA are an under-reported phenomenon.
本研究的目的是回顾已发表的关于透明质酸（HA）填充剂自我注射后并发症的文献。在PubMed和Cochrane数据库中搜索了以下关键词：填充剂与自我注射、透明质酸与自我注射；填充剂与自我给药；透明质酸与自我给药。两位作者独立进行标题和摘要的合格性评估。还筛选了灰色文献以及纳入论文中引用的所有文章，并检查了它们的参考文献列表，以识别其他潜在相关的研究。排除非英文论文。共确定了4例透明质酸自我注射后的并发症。相反，通过谷歌互联网搜索引擎进行一般搜索，输入“透明质酸填充剂自我注射”这一关键词后，有604,000条搜索结果。报道透明质酸自我给药后并发症的文章数量很少。尽管在同一主题的互联网搜索表明，透明质酸填充剂的自我给药在几个在线论坛上是一个广泛讨论的现象。本综述表明，透明质酸自我注射后的并发症是一个报告不足的现象。
