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阿片类药物戒断与电刺激。双盲实验。

Opiate withdrawal and electro-stimulation. Double blind experiments.

作者信息

Ellison F, Ellison W, Daulouede J P, Daubech J F, Pautrizel B, Bourgeois M, Tignol J

机构信息

Centre Carreire, Bordeaux.

出版信息

Encephale. 1987 Jul-Aug;13(4):225-9.

PMID:3311708
Abstract

A rapid detoxification technique for heroin addicts is described. The technique uses an impulsional electric current developed by Limoge. The treatment is nonaggressive, very well tolerated by the addicts and leads to a good psychotherapeutic relationship with the medical staff. A successful physical detoxification is achieved in more than 80% of the cases (this figure is based on 400 patients treated by the method). The technique was subjected to two double-blind experiments. The first experiment tested the real efficacity of the electrical stimulation. The difference between the group of subjects stimulated and the unstimulated control group had a "p-value" which was significant at the 0,5% level. This leads us to believe that the electrical stimulation has a real positive effect. The second experiment reconfirmed the efficacity of the stimulation and showed that 24 hour continuous stimulation was not sufficient to produce a lasting effect. After about 50 hours stimulation a Naloxone test produced little or no reaction in the patients.

摘要

本文描述了一种针对海洛因成瘾者的快速戒毒技术。该技术使用了由利摩日研发的脉冲电流。这种治疗方式并无侵害性,成瘾者对其耐受性良好,且能与医护人员建立良好的心理治疗关系。超过80%的病例成功实现了身体戒毒(这一数据基于400名采用该方法治疗的患者)。该技术进行了两项双盲实验。第一项实验测试了电刺激的实际效果。接受刺激的受试者组与未受刺激的对照组之间的差异,其“p值”在0.5%水平上具有显著性。这使我们相信电刺激具有真正的积极效果。第二项实验再次证实了刺激的效果,并表明24小时持续刺激不足以产生持久效果。在大约50小时的刺激后,纳洛酮测试在患者身上几乎没有产生反应。

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Encephale. 1987 Jul-Aug;13(4):225-9.
2
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The effect of mianserin add-on, on the intensity of opioid withdrawal symptoms during detoxification program--a randomized, double blind, placebo controlled, prospective study.米安色林辅助治疗对戒毒项目中阿片类药物戒断症状强度的影响——一项随机、双盲、安慰剂对照的前瞻性研究。
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["Induced detoxification treatment" of opiate dependent patients--a new therapy concept].
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