Cai Qiong, Xu Wenxiao, Liao Songjie, Liang Yinxing, Wu Chao, Li Xunhua
Department of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases, National Key Clinical Department and Key Discipline of Neurology, Guangdong Provincial Engineering Center for Major Neurological Disease Treatment, Guangdong Provincial Translational Medicine Innovation Platform for Diagnosis and Treatment of Major Neurological Disease, Guangdong Provincial Clinical Research Center for Neurological Diseases, Guangzhou, China.
Front Neurol. 2020 Sep 29;11:571341. doi: 10.3389/fneur.2020.571341. eCollection 2020.
To evaluate the characteristics of F-wave in spinocerebellar ataxia type 3 (SCA3) patients and preclinical carriers of SCA3 gene mutation (PreSCA3), and explore the relationship between disease severity and F-wave parameters and evaluate F-wave parameters as potential biomarkers for monitoring of disease progression in SCA3. We performed F-wave recordings in median, ulnar and tibial nerves of 39 SCA3 patients, 20 PreSCA3, and 27 healthy controls, and compared F-wave parameters between them. In all nerves studied, the mean F-wave amplitude, maximum F-wave amplitude, and F/M amplitude ratio were significantly increased in the SCA3 patients in comparison with the normal controls. And the minimal F-wave latency of SCA3 patients was significantly prolonged and the F-wave persistence (%) was significantly decreased in the median nerve. For the PreSCA3, the maximum F-wave amplitude was significantly higher than normal controls for both median, ulnar, and tibial nerves. The mean F-wave amplitude and F/M amplitude ratio in all nerves were comparable between PreSCA3 and normal controls. The frequency of giant F-wave and frequency of patients with giant F-wave were similar between PreSCA3 and SCA3. The values of F/M amplitude ratio in both median, ulnar, and tibial nerves were correlated positively with disease severity and disease duration. Significant F-wave abnormalities occur in patients with SCA3, even in PreSCA3. F-wave may therefore reveal subclinical alterations and provide objective parameters for evaluating the progression of SCA3.
评估脊髓小脑共济失调3型（SCA3）患者及SCA3基因突变的临床前期携带者（PreSCA3）的F波特征，探讨疾病严重程度与F波参数之间的关系，并评估F波参数作为监测SCA3疾病进展的潜在生物标志物。我们对39例SCA3患者、20例PreSCA3及27例健康对照者的正中神经、尺神经和胫神经进行F波记录，并比较他们之间的F波参数。在所有研究的神经中，与正常对照相比，SCA3患者的平均F波振幅、最大F波振幅及F/M振幅比均显著增加。并且SCA3患者正中神经的最小F波潜伏期显著延长，F波出现率（%）显著降低。对于PreSCA3，正中神经、尺神经和胫神经的最大F波振幅均显著高于正常对照。PreSCA3与正常对照在所有神经中的平均F波振幅及F/M振幅比相当。PreSCA3与SCA3的巨大F波频率及出现巨大F波的患者频率相似。正中神经、尺神经和胫神经的F/M振幅比值均与疾病严重程度和病程呈正相关。SCA3患者甚至PreSCA3患者均出现显著的F波异常。因此，F波可能揭示亚临床改变，并为评估SCA3的进展提供客观参数。
