Huang Lingtong, Fang Xueling, Shi Danrong, Yao Shuhao, Wu Weifang, Fang Qiang, Yao Hangping
Department of Critical Care Units, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
State Key Laboratory for Diagnosis & Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Front Immunol. 2020 Oct 7;11:569082. doi: 10.3389/fimmu.2020.569082. eCollection 2020.
Macrophage-stimulating protein (MSP), a soluble protein mainly synthesized by the liver, is the only known ligand for recepteur d'origine nantais (RON), which is a member of the MET proto-oncogene family. Recent studies show that the MSP-RON signaling pathway not only was important in tumor behavior but also participates in the occurrence or development of many immune system diseases. Activation of RON in macrophages results in the inhibition of nitric oxide synthesis as well as lipopolysaccharide (LPS)-induced inflammatory response. MSP-RON is also associated with chronic inflammatory responses, especially chronic liver inflammation, and might serve as a novel regulator of inflammation, which may affect the metabolism in the body. Another study provided evidence of the relationship between MSP-RON and autoimmune diseases, suggesting a potential role for MSP-RON in the development of drugs for autoimmune diseases. Moreover, MSP-RON plays an important role in maintaining the stability of the tissue microenvironment and contributes to immune escape in the tumor immune microenvironment. Here, we summarize the role of MSP-RON in immunity, based on recent findings, and lay the foundation for further research.
巨噬细胞刺激蛋白（MSP）是一种主要由肝脏合成的可溶性蛋白，是原癌基因MET家族成员——源自南特受体（RON）的唯一已知配体。最近的研究表明，MSP-RON信号通路不仅在肿瘤行为中起重要作用，还参与许多免疫系统疾病的发生或发展。巨噬细胞中RON的激活会导致一氧化氮合成以及脂多糖（LPS）诱导的炎症反应受到抑制。MSP-RON还与慢性炎症反应相关，尤其是慢性肝脏炎症，并且可能作为一种新型炎症调节因子，影响体内代谢。另一项研究提供了MSP-RON与自身免疫性疾病之间关系的证据，表明MSP-RON在自身免疫性疾病药物研发中具有潜在作用。此外，MSP-RON在维持组织微环境的稳定性方面发挥重要作用，并有助于肿瘤免疫微环境中的免疫逃逸。在此，我们基于最近的研究结果总结MSP-RON在免疫中的作用，为进一步研究奠定基础。
