Hahn H J, Kauert C, Kotzke G
Central Institute of Diabetes, Research and Treatment, Karlsburg, GDR.
Exp Clin Endocrinol. 1987 Aug;90(1):46-50. doi: 10.1055/s-0029-1210671.
Cyclosporin A exerts dose- and time-related toxic effects on pancreatic B-cells. We investigated the reversibility of Cyclosporin A-induced alterations on glucose tolerance and pancreatic insulin content in Wistar rats either still normoglycaemic or animals being hyperglycaemic after different treatment periods. Both groups of animals either formerly normoglycaemic but glucose intolerant or hyperglycaemic normalized glucose intolerance, glycaemia and reenhanced pancreatic insulin content. This demonstrates that also hyperglycaemic animals are able to recover spontaneously from a diabetes-like state.
环孢素A对胰腺β细胞产生剂量和时间相关的毒性作用。我们研究了在不同治疗期后仍血糖正常或已出现高血糖的Wistar大鼠中，环孢素A诱导的葡萄糖耐量和胰腺胰岛素含量改变的可逆性。两组动物，无论是先前血糖正常但葡萄糖不耐受的，还是高血糖的，均使葡萄糖不耐受、血糖水平正常化，并提高了胰腺胰岛素含量。这表明高血糖动物也能够从类似糖尿病的状态中自发恢复。
