Hu Shao Wei, Yang Yan Tong, Sun Yuanjie, Zhan Yin Peng, Zhu Yan
State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Beijing 100101, China.
University of Chinese Academy of Sciences, Beijing 100049, China.
iScience. 2020 Oct 6;23(11):101651. doi: 10.1016/j.isci.2020.101651. eCollection 2020 Nov 20.
Traumatic experiences generate stressful neurological effects in the exposed persons and animals. Previous studies have demonstrated that in many species, including , the defeated animal has a higher probability of losing subsequent fights. However, the neural basis of this "loser effect" is largely unknown. We herein report that elevated serotonin (5-HT) signaling helps a loser to overcome suppressive neurological states. Coerced activation of 5-HT neurons increases aggression in males and promotes losers to both vigorously re-engage in fights and even defeat the previous winners and regain mating motivation. P1 neurons act upstream and 5-HT1B neurons in the ellipsoid body act downstream of 5-HT neurons to arouse losers. Our results demonstrate an ancient neural mechanism of regulating depressive behavioral states after distressing events.
创伤性经历会在暴露于其中的人和动物身上产生应激性神经效应。先前的研究表明，在包括 在内的许多物种中，战败的动物在随后的战斗中更有可能失败。然而，这种“失败者效应”的神经基础在很大程度上尚不清楚。我们在此报告，血清素（5-羟色胺，5-HT）信号增强有助于失败者克服抑制性神经状态。强迫激活5-HT神经元会增强雄性的攻击性，并促使失败者积极重新投入战斗，甚至击败先前的胜利者并恢复交配动机。P1神经元在5-HT神经元上游起作用，而椭球体中的5-HT1B神经元在5-HT神经元下游起作用以唤醒失败者。我们的结果证明了一种在痛苦事件后调节抑郁行为状态的古老神经机制。
