神经肽 F 通过一个雄性特异性神经元回路调节 中的求偶行为。
Neuropeptide F regulates courtship in through a male-specific neuronal circuit.
机构信息
Department of Molecular, Cellular and Developmental Biology, and the Neuroscience Research Institute, University of California, Santa Barbara, Santa Barbara, United States.
Institute of Insect Sciences, Zhejiang University, Hangzhou, China.
出版信息
Elife. 2019 Aug 12;8:e49574. doi: 10.7554/eLife.49574.
Abstract
Male courtship is provoked by perception of a potential mate. In addition, the likelihood and intensity of courtship are influenced by recent mating experience, which affects sexual drive. Using , we found that the homolog of mammalian neuropeptide Y, neuropeptide F (NPF), and a cluster of male-specific NPF (NPF) neurons, regulate courtship through affecting courtship drive. Disrupting NPF signaling produces sexually hyperactive males, which are resistant to sexual satiation, and whose courtship is triggered by sub-optimal stimuli. We found that NPF neurons make synaptic connections with P1 neurons, which comprise the courtship decision center. Activation of P1 neurons elevates NPF neuronal activity, which then act through NPF receptor neurons to suppress male courtship, and maintain the proper level of male courtship drive.
摘要
雄性能否求偶取决于其对潜在配偶的感知。此外，求偶的可能性和强度受到近期交配经历的影响，而交配经历会影响性驱力。我们利用果蝇模型发现，与哺乳动物神经肽 Y 同源的神经肽 F（NPF），以及一组雄性特异性的 NPF（NPF）神经元，通过影响求偶驱力来调节求偶行为。破坏 NPF 信号会产生性欲亢进的雄性，它们对性满足不敏感，而且其求偶行为会被次优刺激触发。我们发现，NPF 神经元与 P1 神经元形成突触连接，P1 神经元构成求偶决策中心。激活 P1 神经元会提高 NPF 神经元的活性，进而通过 NPF 受体神经元抑制雄性求偶，维持雄性求偶驱力的适当水平。
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本文引用的文献
1
A Circuit Node that Integrates Convergent Input from Neuromodulatory and Social Behavior-Promoting Neurons to Control Aggression in Drosophila.一个整合来自神经调节和促进社会行为神经元的汇聚输入以控制果蝇攻击行为的电路节点。
Neuron. 2017 Aug 30;95(5):1112-1128.e7. doi: 10.1016/j.neuron.2017.08.017.
2
Neuromodulation of Courtship Drive through Tyramine-Responsive Neurons in the Drosophila Brain.通过果蝇大脑中对酪胺有反应的神经元对求偶驱动力进行神经调节。
Curr Biol. 2016 Sep 12;26(17):2246-56. doi: 10.1016/j.cub.2016.06.061. Epub 2016 Aug 4.
3
Dopaminergic Circuitry Underlying Mating Drive.交配驱动的多巴胺能回路。
Neuron. 2016 Jul 6;91(1):168-81. doi: 10.1016/j.neuron.2016.05.020. Epub 2016 Jun 9.
4
P1 interneurons promote a persistent internal state that enhances inter-male aggression in Drosophila.P1中间神经元促进一种持续的内部状态，这种状态会增强果蝇的雄性间攻击性。
Elife. 2015 Dec 29;4:e11346. doi: 10.7554/eLife.11346.
5
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Elife. 2015 Nov 14;4:e11188. doi: 10.7554/eLife.11188.
6
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Elife. 2015 Sep 21;4:e08477. doi: 10.7554/eLife.08477.
7
Aggression in Drosophila.果蝇的攻击性
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8
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9
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10
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Nat Neurosci. 2015 Jun;18(6):917-25. doi: 10.1038/nn.4016. Epub 2015 May 11.
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