Department of Special Surgery, Faculty of Medicine, Mutah University, Karak, Jordan.
Alkaptonuria Research Office, Faculty of Medicine, Mutah University, Karak, Jordan.
Am J Mens Health. 2020 Sep-Oct;14(5):1557988320969310. doi: 10.1177/1557988320969310.
This study aimed to evaluate the urinary tract for dynamic function and stones and calcifications in patients with alkaptonuria. Thirty-eight patients were prospectively divided into two groups. Study group (A) involved 17 patients; the average age was 42 years. The control group (B) involved 21 patients; the average age was 37 years. All patients from the two groups underwent uroflowmetry assessment and ultrasonography for the kidneys and urinary bladder, and prostate in two phases (full bladder and empty bladder). Group A-Bladder volume ranged between 400 and 520 cc. The peak flow rate was between 7 and 23 mL/s, with an average of 18.6 mL/s. Flow rate curves shape were acceptable to the normal bell-shape curve in 11 patients. Seven patients (41%) had prostate calcification accounting for 5%-35% of prostate size. Group B-Bladder volume ranged between 290 and 510 cc. The peak flow rate was 8-27 ml/s, with an average of 20 mL/sec. Normal bell shape voiding curves were observed in 17 patients (80%). Four patients (19%) had prostate calcification accounting for 2%-12% of prostate size. Renal measurements on ultrasonography were the same in both groups. Patients with alkaptonuria developed prostate calcification at younger age; they have a slight but not statistically significant reduced peak urinary flow rate and post void residual urine.
本研究旨在评估尿路上皮功能和石性疾病及钙化在黑尿酸尿症患者中的表现。38 名患者前瞻性地分为两组。研究组（A 组）纳入 17 例患者，平均年龄为 42 岁。对照组（B 组）纳入 21 例患者，平均年龄为 37 岁。两组患者均进行尿流率评估和肾脏、膀胱及前列腺的超声检查（充盈膀胱和排空膀胱两个阶段）。A 组膀胱容量为 400-520 cc。最大尿流率为 7-23ml/s，平均为 18.6ml/s。11 例患者的尿流率曲线形状呈可接受的正常钟形曲线。7 例患者（41%）有前列腺钙化，占前列腺大小的 5%-35%。B 组膀胱容量为 290-510 cc。最大尿流率为 8-27ml/s，平均为 20ml/s。17 例患者（80%）的尿流率曲线形状呈正常钟形曲线。4 例患者（19%）有前列腺钙化，占前列腺大小的 2%-12%。两组患者的肾脏超声测量结果相同。黑尿酸尿症患者的前列腺钙化发病年龄较轻，最大尿流率和残余尿量虽略有下降，但无统计学意义。
