Hyldegaard Ole, Hedetoft Morten
Ugeskr Laeger. 2020 Oct 26;182(44).
Hypoxia triggers hypoxia-inducible factor (HIF). Not only hypoxia triggers downstream HIF target genes for transcription, as intermittent hyperoxia also possesses similar capabilities, suggesting that fluctuations in oxygen availability may be equally important for inducing HIF transcription. This review describes some of the mechanisms, whereby intermittent hyperbaric hyperoxia may explain some of the observations during hyperbaric oxygen therapy such as enhanced wound healing, angiogenesis and tissue healing, and concludes that oxidative stress enhances certain antibiotics in infection control.
缺氧会触发缺氧诱导因子（HIF）。不仅缺氧会触发下游HIF靶基因进行转录，间歇性高氧也具有类似能力，这表明氧可用性的波动对于诱导HIF转录可能同样重要。本综述描述了一些机制，通过这些机制间歇性高压高氧可能解释高压氧治疗期间的一些观察结果，如伤口愈合增强、血管生成和组织愈合，并得出结论：氧化应激在感染控制中增强了某些抗生素的作用。
