Kivisaari J, Niinikoski J
Acta Chir Scand. 1975;141(1):14-9.
In a study on rats, long-tern intermittent hyperbaric oxygenation at 2 ATA had no effect on the healing rate of open wounds in which the circulation was left intact. When the wound edges were devascularized, however, hyperbaric oxygen enhanced the wound closure rate in the final stages of healing, thus counteracting the delay caused by disturbed blood supply. During the hyperbaric exposure, tissue pO-2 increased considerably in both normal and devascularized skin, whereas tissue pCO-2 increased only slightly. Combined systemic and local hypoxia--12% oxygen at 1 atm--retarded the closure rate of full-thickness skin wounds. This was noted both in acclimatized and in unacclimatized rats. Thirteen-day adaptation to hypoxia increased the healing rate and subcutaneous tissue pO-2 to normal levels, but when hypoxia was continued, tissue pO-2 and the wound closure rate decreased markedly. This was probably due to a decreased blood flow induced by secondary erythrocytosis and an elevated blood viscosity.
在一项针对大鼠的研究中，2个绝对大气压下的长期间歇性高压氧疗对循环未受影响的开放性伤口的愈合速度没有作用。然而，当伤口边缘血管被破坏时，高压氧在愈合的最后阶段提高了伤口闭合速度，从而抵消了因血液供应紊乱导致的延迟。在高压暴露期间，正常皮肤和血管被破坏的皮肤中的组织氧分压均显著升高，而组织二氧化碳分压仅略有升高。全身和局部联合缺氧（1个大气压下12%的氧气）延缓了全层皮肤伤口的闭合速度。这在适应环境和未适应环境的大鼠中均有发现。对缺氧环境进行13天的适应可使愈合速度和皮下组织氧分压提高至正常水平，但当持续缺氧时，组织氧分压和伤口闭合速度显著下降。这可能是由于继发性红细胞增多症导致的血流减少和血液粘度升高所致。
