噻吗洛尔治疗后兔角膜上皮和内皮的超微结构变化。

Ultrastructural changes of the rabbit corneal epithelium and endothelium after Timoptic treatment.

作者信息

Liu G S, Basu P K, Trope G E

机构信息

Department of Ophthalmology, University of Toronto, Ontario, Canada.

出版信息

Graefes Arch Clin Exp Ophthalmol. 1987;225(5):325-30. doi: 10.1007/BF02153398.

DOI:10.1007/BF02153398

PMID:3311892

Abstract

The purpose of this study was to determine whether timolol maleate (Timoptic) is cytotoxic to the cornea. The drug was applied as topical drops for 1 month to control rabbit eyes and rabbit eyes from which the epithelium had been removed or to de-epithelialized full-thickness autografts. Clinically all corneas and grafts remained clear. Scanning and transmission electronmicroscopy however revealed is drug induced epithelial damage, defective epithelial wound healing, and endothelial changes. The endothelial changes were most prominent in the group of rabbits that underwent de-epithelialization before corneal grafting.

摘要

本研究的目的是确定马来酸噻吗洛尔（噻吗心安）对角膜是否具有细胞毒性。将该药物以滴眼液的形式局部应用于对照兔眼、去除上皮的兔眼或去上皮全层自体角膜移植兔眼1个月。临床上，所有角膜和移植物均保持透明。然而，扫描电子显微镜和透射电子显微镜显示该药物可引起上皮损伤、上皮伤口愈合缺陷以及内皮细胞变化。在内皮细胞变化在角膜移植前进行了去上皮处理的兔组中最为明显。