Instituto de Endocrinología y Nutrición.
Centro de Investigación de Endocrinología y Nutrición. Servicio de Endocrinología y Nutrición. Hospital Clínico Universitario de Valladolid.
Nutr Hosp. 2020 Dec 16;37(6):1143-1149. doi: 10.20960/nh.03153.
Objective: the rs10830963 SNP of the MTNR1B gene may be related with biochemical changes after weight loss induced by caloric restriction. We investigated the role of this SNP on biochemical parameters after biliopancreatic diversion (BPD) surgery in morbid obese subjects. Patients and methods: one hundred and fifty-four patients with morbid obesity, without diabetes mellitus type 2, were enrolled. Their biochemical and anthropometric parameters were recorded before the procedure and after one, two, and three years of follow-up. All subjects were genotyped (rs10830963) at baseline. Results: the decrease in fasting insulin levels seen after the first year (delta: -3.9 ± 1.2 mIU/L vs. -1.8 ± 1.1 mIU/L; p = 0.03), the second year (delta: -5.0 ± 0.3 mIU/L vs. -2.3 ± 0.2 mIU/L; p = 0.01) and the third year (delta: -5.1 ± 1.9 mIU/L vs. -2.8 ± 1.1 mIU/L; p = 0.02) was higher in non-G-allele carriers than in G-allele carriers. Additionally, the improvement of HOMA-IR levels at year one (delta: -0.7 ± 0.2 mIU/L vs. -0.2 ± 0.2 mIU/L; p = 0.03), year two (delta: -1.0 ± 0.3 mIU/L vs. -0.5 ± 0.2 mIU/L; p = 0.01) and year three (delta: -1.2 ± 0.3 mIU/L vs. -0.4 ± 0.2 mIU/L; p = 0.03) was also higher in non-G-allele carriers than in G-allele carriers. Finally, basal glucose levels after the first year (delta: -10.1 ± 2.4 mg/dL vs. -3.6 ± 1.8 mg/dL; p = 0.02), the second year (delta: -16.0 ± 2.3 mg/dL vs. -8.4 ± 2.2 mg/dL; p = 0.01) and the third year (delta: -17.4 ± 3.1 mg/dL vs. -8.8 ± 2.9 mg/dL; p = 0.03) were higher in non-G-allele carriers than in G-allele carriers, too. Improvements seen in comorbidities were similar in both genotype groups. Conclusion: our study showed an association of the rs10830963 MTNR1B polymorphism after massive weight loss with lower glucose response, insulin resistance, and fasting insulin levels in G-allele carriers.
MTNR1B 基因的 rs10830963SNP 可能与热量限制引起的体重减轻后的生化变化有关。我们研究了这种 SNP 在病态肥胖患者行胆胰分流术（BPD）后的生化参数中的作用。
共纳入 154 例无 2 型糖尿病的病态肥胖患者。在术前和术后 1、2、3 年记录其生化和人体测量参数。所有患者均在基线时进行 rs10830963 基因分型。
与 G 等位基因携带者相比，非 G 等位基因携带者在术后第 1 年（差值：-3.9 ± 1.2mIU/L 比-1.8 ± 1.1mIU/L；p = 0.03）、第 2 年（差值：-5.0 ± 0.3mIU/L 比-2.3 ± 0.2mIU/L；p = 0.01）和第 3 年（差值：-5.1 ± 1.9mIU/L 比-2.8 ± 1.1mIU/L；p = 0.02）空腹胰岛素水平下降更明显。此外，非 G 等位基因携带者在术后第 1 年（差值：-0.7 ± 0.2mIU/L 比-0.2 ± 0.2mIU/L；p = 0.03）、第 2 年（差值：-1.0 ± 0.3mIU/L 比-0.5 ± 0.2mIU/L；p = 0.01）和第 3 年（差值：-1.2 ± 0.3mIU/L 比-0.4 ± 0.2mIU/L；p = 0.03）时 HOMA-IR 水平的改善也更高。非 G 等位基因携带者在术后第 1 年（差值：-10.1 ± 2.4mg/dL 比-3.6 ± 1.8mg/dL；p = 0.02）、第 2 年（差值：-16.0 ± 2.3mg/dL 比-8.4 ± 2.2mg/dL；p = 0.01）和第 3 年（差值：-17.4 ± 3.1mg/dL 比-8.8 ± 2.9mg/dL；p = 0.03）时基础血糖水平也更高。在两种基因型组中，合并症的改善相似。
我们的研究表明，MTNR1B 基因的 rs10830963 多态性与巨大体重减轻后 G 等位基因携带者的葡萄糖反应、胰岛素抵抗和空腹胰岛素水平降低有关。
