de Luis Daniel, Garcia Calvo Susana, Primo David, Izaola Olatz, Pacheco David
Departamento de Endocrinología y Nutrición, Hospital Clínico Universitario, Valladolid, España; Centro de Investigación de Endocrinología y Nutrición, Facultad de Medicina, Universidad de Valladolid, Valladolid, España.
Departamento de Endocrinología y Nutrición, Hospital Clínico Universitario, Valladolid, España; Centro de Investigación de Endocrinología y Nutrición, Facultad de Medicina, Universidad de Valladolid, Valladolid, España.
Endocrinol Diabetes Nutr (Engl Ed). 2019 Mar;66(3):157-163. doi: 10.1016/j.endinu.2018.09.008. Epub 2018 Dec 26.
The role of genetic variants of the CB2R gene in weight loss after a dietary intervention has been investigated in few studies, none of which has been conducted after bariatric surgery.
The aim of this study was to assess the effect of the genetic variant (rs3123554) of the CB2R gene on cardiovascular risk factors and weight loss secondary to a biliopancreatic diversion.
The study simple consisted of 147 patients with morbid obesity. Biochemical and anthropometric parameters were measured at baseline and at each visit during 3 years (1, 2, and 3 years).
Percent excess weight loss, body mass index, weight, waist circumference, fat mass, blood pressure, fasting glucose, LDL cholesterol, total cholesterol, insulin, HOMA-IR, and triglyceride levels improved in both genotype groups. Decreases in fasting insulin levels and HOMA-IR were higher in non-A allele carriers as compared to A allele carriers.
Our data suggest that patients with morbid obesity who undergo bariatric surgery and carry the A allele of variant rs3123554 of the CB2R gene have greater weight. This allele has no influence on weight loss after surgery, but results in a lower decrease in insulin levels and insulin resistance.
少数研究调查了CB2R基因的遗传变异在饮食干预后体重减轻中的作用，但均未在减肥手术后进行。
本研究旨在评估CB2R基因的遗传变异（rs3123554）对胆胰转流术后心血管危险因素和体重减轻的影响。
该研究简单地纳入了147例病态肥胖患者。在基线以及3年（第1、2和3年）的每次随访时测量生化和人体测量参数。
两个基因型组的超重减轻百分比、体重指数、体重、腰围、脂肪量、血压、空腹血糖、低密度脂蛋白胆固醇、总胆固醇、胰岛素、HOMA-IR和甘油三酯水平均有所改善。与A等位基因携带者相比，非A等位基因携带者的空腹胰岛素水平和HOMA-IR下降幅度更大。
我们的数据表明，接受减肥手术且携带CB2R基因变异rs3123554的A等位基因的病态肥胖患者体重更重。该等位基因对术后体重减轻没有影响，但导致胰岛素水平和胰岛素抵抗的下降幅度较小。
