Department of Surgical Oncology. Medical University of Gdańsk.
Department of Human Nutrition and Metabolomics. Pomeranian Medical University in Szczecin.
Nutr Hosp. 2020 Dec 16;37(6):1179-1185. doi: 10.20960/nh.03185.
Introduction: the nutritional status of cancer patients should be screened regularly due to their high risk of malnutrition, which impairs patient quality of life (QoL). Therefore, an assessment of nutritional status is strongly necessary. Recently, the Global Leadership Initiative on Malnutrition (GLIM) criteria for assessing the severity of malnutrition were published (2019). Objectives: the primary aim of this study was the assessment of nutritional status and QoL in advanced cancer patients. A secondary aim was to investigate the impact of malnutrition severity on QoL in these patients. Methods: this study included 33 advanced cancer patients (head/neck, esophageal, gastric) from the Nutritional Counselling Centre Copernicus in Gdansk, and the Department of Surgical Oncology, Medical University of Gdansk, Poland. The assessment of nutritional status was conducted with the 2019 GLIM criteria and the Subjective Global Assessment (SGA) method. QoL was assessed using the World Health Organization Quality of Life-BREF questionnaire (WHOQOL-BREF). Results: according to the SGA method, most of the patients were malnourished (42.42 %) or severely malnourished (42.42 %). Based on the GLIM criteria, 69.7 % of patients (n = 23) were severely malnourished. Among all participants, the highest impairments of QoL were observed in the environmental and psychological domains of the self-assessed satisfaction with own health questionnaire. Severe malnutrition significantly impairs QoL in the psychological (GLIM stage 2, p = 0.0033; SGA C, p = 0.0310) and somatic domains (GLIM stage 2, p = 0.0423). Conclusions: most patients with advanced cancer are malnourished or severely malnourished. Overall, the QoL of these patients is impaired. The severity of malnutrition has an impact on the QoL of cancer patients, which is observed as an impairment of mainly psychological and somatic aspects. This is the first study assessing the impact of malnutrition severity, as based on the new 2019 GLIM criteria, on the QoL of advanced cancer patients.
由于癌症患者存在营养不良的高风险，会损害患者的生活质量（QoL），因此应定期对其营养状况进行筛查。因此，对营养状况进行评估是非常必要的。最近，全球营养不良领导倡议（GLIM）发布了评估营养不良严重程度的标准（2019 年）。目的：本研究的主要目的是评估晚期癌症患者的营养状况和生活质量。次要目的是调查这些患者的营养不良严重程度对生活质量的影响。方法：本研究纳入了来自波兰格但斯克哥白尼营养咨询中心和格但斯克医科大学外科肿瘤学系的 33 例晚期癌症患者（头颈部、食管、胃）。营养状况评估采用 2019 年 GLIM 标准和主观全面评估（SGA）方法。生活质量采用世界卫生组织生活质量简表（WHOQOL-BREF）进行评估。结果：根据 SGA 方法，大多数患者存在营养不良（42.42%）或严重营养不良（42.42%）。根据 GLIM 标准，69.7%的患者（n=23）存在严重营养不良。在所有参与者中，自我评估对自身健康满意度问卷的环境和心理领域的生活质量受损最严重。严重营养不良显著影响生活质量的心理（GLIM 阶段 2，p=0.0033；SGA C，p=0.0310）和躯体领域（GLIM 阶段 2，p=0.0423）。结论：大多数晚期癌症患者存在营养不良或严重营养不良。总体而言，这些患者的生活质量受损。营养不良的严重程度对癌症患者的生活质量有影响，主要表现在心理和躯体方面的受损。这是第一项评估基于新的 2019 GLIM 标准的营养不良严重程度对晚期癌症患者生活质量影响的研究。
