Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Ain Shams University , Cairo, Egypt.
Dermatology and Laser Dermatology Unit, Department of Medical Applications of Laser, National Institute of Laser Enhanced Sciences, Cairo University , Cairo, Egypt.
Expert Opin Drug Deliv. 2021 Jan;18(1):139-150. doi: 10.1080/17425247.2021.1844180. Epub 2020 Nov 11.
: Bergamot oil (BO) is a photosensitizer that can be used for photodynamic therapy (PDT) of dermatological diseases such as vitiligo. Being an oil, it can be integrated within the lipidic matrix of nanostructured lipid carriers (NLCs) as the liquid lipid constituent, hence exhibiting a dual role. : NLCs were prepared with different emulsifiers and coemulsifiers, and the effect of the preparation method and formulation variables on the NLCs' size was elucidated. The prepared NLCs were further characterized for their in vitro release, viscosity, thermal behavior, and in vitro photostability. Furthermore, a preclinical photodynamic study on animal skin was conducted, followed by clinical experimentation on patients with vitiligo. : Results showed that BO was successfully incorporated within the NLCs. The selected NLCs formulation was in the nanometer range with a gel consistency, and it provided sustained release of BO for 24 h. NLCs improved the photostability and photodynamic properties of BO, and displayed promising preclinical and clinical results for the topical PDT of vitiligo. : BO containing NLCs was proven to be promising means for PDT of vitiligo, and can be further explored in other dermatological diseases.
佛手柑油（BO）是一种光敏剂，可用于治疗白癜风等皮肤病的光动力疗法（PDT）。作为一种油，它可以作为液体脂质成分整合到纳米结构化脂质载体（NLC）的脂质基质中，从而发挥双重作用。我们使用不同的乳化剂和共乳化剂制备了 NLC，并阐明了制备方法和配方变量对 NLC 尺寸的影响。进一步对制备的 NLC 进行了体外释放、粘度、热行为和体外光稳定性的表征。此外，还在动物皮肤上进行了临床前光动力研究，然后在白癜风患者中进行了临床实验。结果表明，BO 成功地掺入了 NLC 中。所选的 NLC 制剂在纳米范围内具有凝胶稠度，可提供 24 小时的 BO 持续释放。NLC 提高了 BO 的光稳定性和光动力性能，为白癜风的局部 PDT 提供了有前景的临床前和临床结果。含有 BO 的 NLC 被证明是治疗白癜风 PDT 的有前途的方法，并可在其他皮肤病中进一步探索。
