Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.
Dermatology and Laser Dermatology Unit, Department of Medical Applications of Laser, National Institute of Laser Enhanced Sciences, Cairo University, Cairo, Egypt.
Drug Deliv Transl Res. 2019 Dec;9(6):1106-1116. doi: 10.1007/s13346-019-00653-y.
The impact of nanomedicine has grown in the current decade; however, only very few clinical translational attempts have been realized. Therefore in the present study, we hypothesized that bergamot oil, a psoralen-containing oil, would produce an optimized melanogenic effect in the clinical treatment of vitiligo when loaded within an elastic nanocarrier (spanlastics) and combined with PUVB for activation of psoralens. Spanlastics were prepared and characterized for particle size, physical stability, in vitro release, thermal behavior, deformability, morphology, and in vitro photostability. The efficacy of the selected formula was tested histopathologically on rat skin and clinically translated in patients suffering from vitiligo. Results revealed that the spanlastics were of reasonable nanosize, deformable, and provided sustained release of bergamot oil. The incorporation of bergamot oil within spanlastics improved its photostability and its photodynamic activity. Spanlastics exhibited promising clinical results in terms of extent and onset of repigmentation in vitiligo patients. Therefore, it can be concluded that spanlastics can be introduced as a promising nanotreatment modality for vitiligo.
在当前十年中，纳米医学的影响力不断增长；然而，仅有极少数临床转化尝试得以实现。因此，在本研究中，我们假设当佛手柑油（一种含有补骨脂素的油）被负载在弹性纳米载体（spanlastics）中并与 PUVB 结合以激活补骨脂素时，它将在白癜风的临床治疗中产生优化的黑色素生成效果。spanlastics 被制备并进行了粒径、物理稳定性、体外释放、热行为、变形性、形态和体外光稳定性的表征。选择的配方在大鼠皮肤上进行了组织病理学评估，并在患有白癜风的患者中进行了临床转化。结果表明，spanlastics 的纳米尺寸合理、可变形，并提供了佛手柑油的持续释放。将佛手柑油掺入 spanlastics 提高了其光稳定性和光动力活性。spanlastics 在白癜风患者的色素沉着恢复程度和开始时间方面表现出有希望的临床效果。因此，可以得出结论，spanlastics 可以作为一种有前途的白癜风纳米治疗方法引入。
