Onji M, Kumon I, Kanaoka M, Horiike N, Ohta Y
Third Department of Internal Medicine, Ehime University School of Medicine, Japan.
Hepatogastroenterology. 1987 Aug;34(4):141-4.
Intrahepatic lymphocyte subpopulations were studied in 11 patients with fulminant hepatitis (FH) (of whom 9 cases died) by the immunoenzymatic technique, using monoclonal T cell specific antibodies and other reagents. In peripheral blood, the OKT4 positive cells: OKT8 positive cells ratio in FH was higher than that in normal controls. In liver tissue, OKT8 positive cells were the predominant type of T cells, and these cells were in broad contact with the surface of the hepatocyte. Leu7 positive, OKT4/4a positive and Leu 15 positive cells were scarce and did not contact the hepatocyte. These results suggest that cytotoxic T cells may play an important role in hepatocyte necrosis in patients with FH.
采用免疫酶技术，使用单克隆T细胞特异性抗体及其他试剂，对11例暴发性肝炎（FH）患者（其中9例死亡）的肝内淋巴细胞亚群进行了研究。在外周血中，FH患者的OKT4阳性细胞与OKT8阳性细胞的比例高于正常对照组。在肝组织中，OKT8阳性细胞是T细胞的主要类型，这些细胞与肝细胞表面广泛接触。Leu7阳性、OKT4/4a阳性和Leu 15阳性细胞稀少，且不与肝细胞接触。这些结果表明，细胞毒性T细胞可能在FH患者的肝细胞坏死中起重要作用。
