Onji M, Kumon I, Kanaoka M, Miyaoka H, Ohta Y
Third Department of Internal Medicine, Ehime University School of Medicine, Japan.
Am J Gastroenterol. 1988 Mar;83(3):320-2.
Rubella accompanied by serum aminotransferase elevations occurred in a 24-yr-old man. Liver biopsy showed ballooning degeneration and focal necrosis of liver cells, clumped Kupffer cells, and infiltration of inflammatory cells, mainly of the mononuclear type. Most mononuclear cells in the liver were CD8-positive and CD16-negative cells (cytotoxic T cells) which were in broad contact with the surface of liver cells. Leu 7 (natural killer) cells were few and sporadic. HLA class I antigens were expressed on liver cell membrane. Although hepatic involvement in adult rubella is not generally recognized, it may have been the cause of this patient's liver injury. Thus, cytotoxic T cells may play a role in liver injury in acute rubella infections in adults.
一名24岁男性患风疹并伴有血清转氨酶升高。肝脏活检显示肝细胞气球样变性和灶性坏死、库普弗细胞聚集以及炎症细胞浸润，主要为单核细胞类型。肝脏中的大多数单核细胞是CD8阳性和CD16阴性细胞（细胞毒性T细胞），它们与肝细胞表面广泛接触。Leu 7（自然杀伤）细胞很少且散在分布。HLA I类抗原在肝细胞膜上表达。尽管成人风疹的肝脏受累情况通常未被认识到，但它可能是该患者肝损伤的原因。因此，细胞毒性T细胞可能在成人急性风疹感染的肝损伤中起作用。
