Biopathology and Regenerative Medicine Institute (IBIMER), Centre for Biomedical Research (CIBM), University of Granada, Granada, Spain.
Instituto de Investigación Biosanitaria ibs.GRANADA, University Hospitals of Granada-University of Granada, Granada, Spain.
Adv Exp Med Biol. 2020;1277:115-126. doi: 10.1007/978-3-030-50224-9_8.
The importance of the microenvironment in tumor development and their resistance to drugs is increasingly well known. This microenvironment is composed of different cell types, among which cells with stemness properties such as cancer stem cells (CSCs) and mesenchymal stem cells (MSCs) are distinguished for their relevant role in tumor proliferation, angiogenesis, metastasis, and drug resistance. The relationship between these stem cells (SCs) and tumor microenvironment is conducted by the secretome, consisting of several factors, cytokines, chemokines, and hormones released to the surrounding stroma, which plays a deterministic role in tumor hallmarks. Knowing the intrinsic and complex communication network that SCs establish with the microenvironment will allow to address the tumor processes responsible for cancer progression and the generation of new targeted therapeutic approaches useful in the clinic arena.
肿瘤微环境在肿瘤发生和耐药中的重要性日益为人们所认识。该微环境由不同的细胞类型组成，其中具有干性特征的细胞，如癌症干细胞（CSCs）和间充质干细胞（MSCs），因其在肿瘤增殖、血管生成、转移和耐药中的相关作用而被区分开来。这些干细胞（SCs）与肿瘤微环境之间的关系是通过由几种因子组成的分泌组来进行的，包括细胞因子、趋化因子和激素释放到周围基质中，这些因子在肿瘤特征中起着决定性的作用。了解SCs 与微环境建立的内在和复杂的通信网络，将有助于解决导致癌症进展的肿瘤过程，并产生新的、有用的临床靶向治疗方法。
