Department of Physiology and Biophysics, University of Mississippi Medical Center , Jackson, MS, USA.
Department of Pharmacology and Toxicology, University of Mississippi Medical Center , Jackson, MS, USA.
Hypertens Pregnancy. 2020 Nov;39(4):451-460. doi: 10.1080/10641955.2020.1833215. Epub 2020 Oct 29.
Women with preeclampsia (PE) and reduced uterine perfusion pressure (RUPP) pre-clinical rat model of PE have elevated angiotensin II type 1 receptor agonistic autoantibodies (AT1-AA) and cerebrovascular dysfunction. Sprague Dawley rats had RUPP surgery with/without AT1-AA inhibitor ('n7AAc'144 μg/day) osmotic minipumps. Mean arterial pressure (MAP), CBF autoregulation, blood brain barrier (BBB) permeability, cerebral edema, oxidative stress, and eNOS were assessed. 'n7AAc' improved MAP, restored CBF autoregulation, prevented cerebral edema, elevated oxidative stress, and increased phosphorylated eNOS protein in RUPP rats. Inhibiting the AT1-AA in placental ischemic rats prevents hypertension, cerebrovascular dysfunction, and improves cerebral metabolic function.
患有子痫前期（PE）和子宫灌注压降低（RUPP）的女性的临床前 PE 大鼠模型具有升高的血管紧张素 II 型 1 受体激动性自身抗体（AT1-AA）和脑血管功能障碍。Sprague Dawley 大鼠接受 RUPP 手术，同时给予/不给予 AT1-AA 抑制剂（'n7AAc'144 μg/天）渗透微型泵。评估平均动脉压（MAP）、CBF 自动调节、血脑屏障（BBB）通透性、脑水肿、氧化应激和 eNOS。'n7AAc'改善了 MAP，恢复了 CBF 自动调节，预防了脑水肿，增加了氧化应激，并增加了 RUPP 大鼠中磷酸化的 eNOS 蛋白。在胎盘缺血大鼠中抑制 AT1-AA 可预防高血压、脑血管功能障碍，并改善脑代谢功能。
