Department of Pharmaceutics, Ghent University, Ghent, 9000, Belgium.
Laboratory for Surface Science and Technology, Department of Materials, ETH Zürich, Zürich, Switzerland; Biointerfaces, Swiss Federal Laboratories for Materials Science and Technology (Empa), St. Gallen, Switzerland.
Biomaterials. 2021 Jan;267:120468. doi: 10.1016/j.biomaterials.2020.120468. Epub 2020 Oct 19.
Cyclic polymers are an intriguing class of polymers due to their lack of chain ends. This unique architecture combined with steric constraints adorn cyclic polymers as well as nano-, micro- and macro-scale materials containing cyclic polymers with distinctive physicochemical properties which can have a profound effect on the performance of these materials in a wide range of applications. Within a biomedical context, biomaterials based on cyclic polymers have shown very distinct properties in terms of biodistribution, pharmacokinetics, drug/gene delivery efficiency and surface activity. This review summarizes the applications of cyclic polymers in the field of biomaterials and highlights their potential in the biomedical field as well as addressing future challenges in this area.
环状聚合物由于其缺乏链末端而成为一类引人入胜的聚合物。这种独特的结构与空间位阻相结合，使环状聚合物以及纳米、微米和宏观尺度的材料具有独特的物理化学性质，这对这些材料在广泛应用中的性能有深远的影响。在生物医学背景下，基于环状聚合物的生物材料在生物分布、药代动力学、药物/基因传递效率和表面活性方面表现出非常独特的性质。本文综述了环状聚合物在生物材料领域的应用，并强调了它们在生物医学领域的潜力，以及解决该领域未来面临的挑战。
