Department of Chemistry and Biochemistry, University of Notre Dame, Indiana, USA.
Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2020 Nov;12(6):e1640. doi: 10.1002/wnan.1640. Epub 2020 May 4.
Hyperbranched polymers represent an intriguing class of shape-persistent soft nanomaterials that could be easily produced in one-pot reaction to obtain highly branched arborescent structures. Although traditional synthesis of hyperbranched polymers suffers from the poorly defined structures and broad molecular weight distribution, recent progress on synthesis methods allows the production of structurally defined polymers in tunable molecular weights, composition and degree of branching. This review summarizes the recent advance on synthesis of hyperbranched polymers and their applications as biomaterials in tissue engineering scaffolds, diagnostic probe carriers and drug delivery fields. This article is categorized under: Implantable Materials and Surgical Technologies > Nanomaterials and Implants Nanotechnology Approaches to Biology > Nanoscale Systems in Biology.
超支化聚合物是一类引人入胜的形态保持型软纳 米材料，它们可以通过一锅法轻松制备，得到高度支化的树状结构。尽管传统的超支化聚合物合成存在结构定义不明确和分子量分布较宽的问题，但最近在合成方法上的进展使得可以在可调分子量、组成和支化度下生产结构明确的聚合物。本文综述了超支化聚合物的最新合成进展及其在组织工程支架、诊断探针载体和药物输送领域作为生物材料的应用。本文属于以下分类：可植入材料和外科技术 > 纳米材料和植入物 纳米生物技术 > 生物学中的纳米系统。
