次氯酸抗菌冲洗可提高玻璃体内注射后的患者舒适度：一项患者报告结局研究。
Hypochlorous acid antiseptic washout improves patient comfort after intravitreal injection: A patient reported outcomes study.
作者信息
Fam Anthony, Finger Paul T, Tomar Ankit S, Garg Gaurav, Chin Kimberly J
机构信息
The New York Eye Cancer Center, New York, New York, USA.
出版信息
Indian J Ophthalmol. 2020 Nov;68(11):2439-2444. doi: 10.4103/ijo.IJO_2001_20.
PURPOSE
Current ocular antiseptic practice for intravitreal injection (IVI) employs 5% povidone-iodine (Betadine) drops which frequently cause ocular discomfort and prolonged irritation. In an effort to improve comfort while maintaining efficacy, we studied a hypochlorous acid (HOCL 0.01%) spray washout prior to injection.
METHODS
Patients had received a minimum of 3 IVIs prepared with Betadineantisepsis prior to entry in this study. Their subsequent IVIs were prepared with Betadinefollowed by HOCL 0.01% washout. Facets of comfort were measured by a Likert-scaled questionnaire to compare their experiences after IVI.
RESULTS
Thirty-seven participants were enrolled. Addition of HOCL 0.01% spray after Betadinereduced the duration of discomfort (P = 0.001) and need for artificial tears postinjection (P = 0.003). It improved their reported quality of life (P = 0.04) and sleep (P = 0.01). There were neither HOCL-related side effects nor endophthalmitis during this study.
CONCLUSION
Topical HOCL 0.01% spray after topical Betadineantisepsis significantly improved patient comfort following IVIs.
目的
目前玻璃体内注射（IVI）的眼部消毒方法采用5%聚维酮碘（碘伏）滴眼液，这常常会引起眼部不适和持续性刺激。为了在保持疗效的同时提高舒适度，我们研究了在注射前使用次氯酸（HOCL 0.01%）喷雾冲洗。
方法
在进入本研究之前，患者至少接受过3次使用碘伏消毒进行的玻璃体内注射。他们随后的玻璃体内注射先用碘伏消毒，然后用HOCL 0.01%冲洗。通过李克特量表问卷来衡量舒适度方面，以比较他们在玻璃体内注射后的体验。
结果
招募了37名参与者。在碘伏消毒后添加HOCL 0.01%喷雾可缩短不适持续时间（P = 0.001），并减少注射后使用人工泪液的需求（P = 0.003）。它改善了他们报告的生活质量（P = 0.04）和睡眠（P = 0.01）。在本研究期间，既没有与HOCL相关的副作用，也没有发生眼内炎。
结论
在局部使用碘伏消毒后使用局部HOCL 0.01%喷雾可显著提高玻璃体内注射后患者的舒适度。
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