Takahashi Atsushi, Abe Masanori, Yasunaka Tetsuya, Arinaga-Hino Teruko, Abe Kazumichi, Takaki Akinobu, Torimura Takuji, Zeniya Mikio, Yoshizawea Kaname, Kang Jong-Hon, Suzuki Yoshiyuki, Nakamoto Nobuhiro, Inui Ayano, Tanaka Atsushi, Takikawa Hajime, Ohira Hiromasa
Department of Gastroenterology, Fukushima Medical University School of Medicine, Hikarigaoka, Fukushima.
Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Shitsukawa, To-on, Ehime.
Medicine (Baltimore). 2020 Oct 23;99(43):e22764. doi: 10.1097/MD.0000000000022764.
Health-related quality of life (HRQOL) is lower in individuals with autoimmune hepatitis (AIH) than in the general population. However, previous evaluations of HRQOL for AIH have included a broad range of disease activities. The aim of this study was to clarify HRQOL among patients with AIH in remission.We assessed HRQOL in patients with AIH in remission, patients with chronic hepatitis C (CHC) with eradicated hepatitis C virus (HCV) and patients with primary biliary cholangitis (PBC) using the Japanese version of the Chronic Liver Disease Questionnaire (CLDQ).Participants comprised 62 patients with AIH in remission, 39 patients with CHC with eradicated HCV and 66 patients with PBC. Median ages of patients were 63, 69, and 64 years, respectively. Overall score (5.6 vs 5.9, P = .02) and fatigue (5.2 vs 5.6, P = .01) and worry (5.6 vs 6.0, P = .01) domain scores of the CLDQ were significantly lower in patients with AIH in remission than in CHC with eradicated HCV, and similar to scores except for the systemic symptoms domain in patients with PBC. Disease duration was associated with lower scores on systemic symptoms and activity domains of the CLDQ in patients with AIH in remission.Patients with AIH in remission show impaired HRQOL associated with disease duration.
自身免疫性肝炎（AIH）患者的健康相关生活质量（HRQOL）低于普通人群。然而，先前对AIH患者HRQOL的评估涵盖了广泛的疾病活动情况。本研究的目的是明确缓解期AIH患者的HRQOL。我们使用日语版慢性肝病问卷（CLDQ）对缓解期AIH患者、丙型肝炎病毒（HCV）已清除的慢性丙型肝炎（CHC）患者和原发性胆汁性胆管炎（PBC）患者的HRQOL进行了评估。参与者包括62例缓解期AIH患者、39例HCV已清除的CHC患者和66例PBC患者。患者的中位年龄分别为63岁、69岁和64岁。缓解期AIH患者CLDQ的总体评分（5.6对5.9，P = 0.02）、疲劳评分（5.2对5.6，P = 0.01）和担忧评分（5.6对6.0，P = 0.01）显著低于HCV已清除的CHC患者，与PBC患者除全身症状领域外的评分相似。疾病持续时间与缓解期AIH患者CLDQ全身症状和活动领域的较低评分相关。缓解期AIH患者的HRQOL受损，且与疾病持续时间有关。
