Department of Medicine, Teikyo University School of Medicine, Tokyo, Japan.
Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Ehime, Japan.
Sci Rep. 2018 Aug 22;8(1):12542. doi: 10.1038/s41598-018-31063-8.
Although patients with primary biliary cholangitis (PBC) experience a variety of symptoms that could impair health-related quality of life (HRQOL), no studies regarding symptoms and impact of PBC on HRQOL have been performed in Asian countries. Herein, we aimed to evaluate symptoms and HRQOL in Japanese PBC patients. We performed a multicenter, observational, cross-sectional study. The PBC-40 and the short form (SF)-36 were used as measures of symptoms and HRQOL. Four-hundred-ninety-six patients with PBC were enrolled. In the PBC-40, the average score was highest in the emotional domain, followed by the fatigue domain. The HRQOL measured using SF-36 was also impaired, especially in the physical and role-social components. After adjustments of variables, female sex, younger age at diagnosis, and lower serum albumin level were independently associated with fatigue scores, while a longer follow-up period and lower serum albumin levels were associated with itch scores.
尽管原发性胆汁性胆管炎 (PBC) 患者会出现多种可能影响健康相关生活质量 (HRQOL) 的症状，但在亚洲国家尚未开展针对 PBC 患者症状及其对 HRQOL 影响的研究。在此，我们旨在评估日本 PBC 患者的症状和 HRQOL。我们进行了一项多中心、观察性、横断面研究。采用 PBC-40 和简明健康调查问卷 (SF-36) 评估症状和 HRQOL。共纳入 496 例 PBC 患者。在 PBC-40 中，平均得分最高的是情绪领域，其次是疲劳领域。SF-36 测量的 HRQOL 也受到损害，特别是在身体和角色-社会功能方面。在调整变量后，女性、诊断时年龄较小和较低的血清白蛋白水平与疲劳评分独立相关，而更长的随访时间和较低的血清白蛋白水平与瘙痒评分相关。
