Zhang Jianfeng, Liu Yunxia, Xu Yefeng
Zhejiang Chinese Medical University.
Department of Oncology, The Third People's Hospital of Hangzhou, Hangzhou, Zhejiang, China.
Medicine (Baltimore). 2020 Oct 23;99(43):e22797. doi: 10.1097/MD.0000000000022797.
Cancer-related depression (CRD) is the most common mood disorder in patients with malignant tumors, negatively influencing the patient's daily life. Traditional Chinese medicine, as an alternative CRD therapy, has shown good treatment performance in recently years. Soothing liver-qi stagnation, as a classic therapy for depression, is based on traditional Chinese medicine theory. However, there is no evidence-based medical confirmation for the soothing liver-qi stagnation method for CRD treatment.
We will systematically search relevant articles from their inception to July 1, 2019 in the following electronic databases: the Cochrane Library, PubMed, EMBASE, Chinese National Knowledge Infrastructure Database, Chinese Biomedical Literature Database, Chinese Science and Technique Journals Database, and the Wan-fang Database. The primary outcome is the total scores of the Hamilton rating scale for depression and, the efficacy rate of reducing Hamilton rating scale for depression scores. The secondary outcomes are adverse reactions and quality of life as assessed by standard instruments. Two researchers will independently perform study selection, data extraction, and quality assessment. If there is any disagreement, it will be settled through third-party negotiations. We will assess the risk of bias and data synthesis using Review Manager (the Cochrane Collaboration) software, Version 5.3.0.
This work will evaluate the clinical effectiveness and safety of the soothing liver-qi stagnation method for CRD.
This study may provide evidence-based medical corroboration for clinical application of the soothing liver-qi stagnation method for CRD treatment.
CRD42019145678.
癌症相关抑郁（CRD）是恶性肿瘤患者中最常见的情绪障碍，对患者的日常生活产生负面影响。近年来，中医作为一种替代的CRD治疗方法，已显示出良好的治疗效果。疏肝理气作为一种经典的抑郁症治疗方法，是基于中医理论。然而，对于疏肝理气法治疗CRD尚无循证医学的确证。
我们将系统检索以下电子数据库从建库至2019年7月1日的相关文章：Cochrane图书馆、PubMed、EMBASE、中国知网数据库、中国生物医学文献数据库、中国科技期刊数据库和万方数据库。主要结局是汉密尔顿抑郁评定量表总分以及汉密尔顿抑郁评定量表评分降低的有效率。次要结局是通过标准工具评估的不良反应和生活质量。两名研究人员将独立进行研究选择、数据提取和质量评估。如有分歧，将通过第三方协商解决。我们将使用Review Manager（Cochrane协作网）软件5.3.0版评估偏倚风险和数据合成。
本研究将评估疏肝理气法治疗CRD的临床有效性和安全性。
本研究可能为疏肝理气法治疗CRD的临床应用提供循证医学确证。
PROSPERO注册号：CRD42019145678。
