Department of Biotechnology, Alagappa University, Science Campus, Karaikudi, Tamil Nadu 630003, India.
Department of Horticultural Science, Mokpo National University, Muan, Jeonnam 534-729, Korea.
Molecules. 2020 Oct 27;25(21):4962. doi: 10.3390/molecules25214962.
Our recently published in vivo studies and growing evidence suggest that moderate consumption of beer possesses several health benefits, including antioxidant and cardiovascular effects. Although beer contains phenolic acids and flavonoids as the major composition, and upon consumption, the levels of major components increase in the blood, there is no report on how these beer components interact with main human serum proteins. Thus, to address the interaction potential between beer components and human serum proteins, the present study primarily aims to investigate the components of beer from different industrial sources as well as their mode of interaction through in silico analysis. The contents of the bioactive compounds, antioxidant capacities and their influence on binding properties of the main serum proteins in human metabolism (human serum albumin (HSA), plasma circulation fibrinogen (PCF), C-reactive protein (CRP) and glutathione peroxidase 3 (GPX3)) were studied. In vitro and in silico studies indicated that phenolic substances presented in beer interact with the key regions of the proteins to enhance their antioxidant and health properties. We hypothesize that moderate consumption of beer could be beneficial for patients suffering from coronary artery disease (CAD) and other health advantages by regulating the serum proteins.
我们最近发表的体内研究和不断增加的证据表明，适量饮用啤酒具有多种健康益处，包括抗氧化和心血管作用。尽管啤酒含有酚酸和类黄酮等主要成分，并且在饮用后，血液中的主要成分水平会增加，但目前尚无关于这些啤酒成分如何与主要人血清蛋白相互作用的报告。因此，为了研究啤酒成分与人血清蛋白之间的相互作用潜力，本研究主要旨在通过计算机模拟分析研究不同工业来源的啤酒成分及其相互作用模式。研究了来自不同工业来源的啤酒的生物活性化合物含量、抗氧化能力及其对人代谢中主要血清蛋白（人血清白蛋白 (HSA)、血浆循环纤维蛋白原 (PCF)、C 反应蛋白 (CRP) 和谷胱甘肽过氧化物酶 3 (GPX3)）结合特性的影响。体外和计算机模拟研究表明，啤酒中存在的酚类物质与蛋白质的关键区域相互作用，增强了它们的抗氧化和健康特性。我们假设，通过调节血清蛋白，适量饮用啤酒可能对患有冠心病 (CAD) 和其他健康优势的患者有益。
