Gorinstein Shela, Caspi Abraham, Libman Imanuel, Leontowicz Hanna, Leontowicz Maria, Tashma Zev, Katrich Elena, Jastrzebski Zenon, Trakhtenberg Simon
Department of Medicinal Chemistry and Natural Products, The Hebrew University-Hadassah Medical School, Jerusalem, Israel.
Int J Food Sci Nutr. 2007 Mar;58(2):94-107. doi: 10.1080/09637480601108661.
Extracted total phenols, flavanols and flavonoids were measured in beer samples and their quality as antioxidants was measured by two modified antioxidant methods: the 2,2'-azinobis (3-ethylbenzothiazoline-6-sulfonate) radical cation (ABTS * +) and the beta-carotene-linoleate model system (beta-carotene). It was found that the antioxidant potential of beer was well correlated with flavanols and flavonoids and was slightly lower with total polyphenols (R2 values from 0.8203 to 0.9393). Forty-two male non drinkers, hypercholesterolaemic volunteers ages 43-71 after coronary bypass surgery, were randomly divided into experimental (EG) and control (CG) groups, each of 21 participants. The antiatherosclerotic diet of the EG group was supplemented for 30 consecutive days with 330 ml beer per day. Could short-term beer consumption affect not only the risk factors of coronary atherosclerosis, but also the markers of this process: plasma albumin and its antioxidant activity? For this goal, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, plasma albumin and fibrinogen, and the antioxidant activity were determined. After the trial a significant improvement in the plasma lipid levels, and an increase in the plasma antioxidant and anticoagulant activities in patients of the EG group was registered. A parallel increase in the plasma albumin concentration and its antioxidant activity was observed. In conclusion, short-term beer consumption on the basis of the bioactivity of the beverage positively affects plasma lipid levels, plasma antioxidant and anticoagulant activities. The increase in the plasma albumin concentration and its antioxidant activity could be the markers of atherosclerosis status.
对啤酒样品中提取的总酚、黄烷醇和黄酮类化合物进行了测定，并通过两种改良的抗氧化方法测定了它们作为抗氧化剂的质量：2,2'-偶氮二（3-乙基苯并噻唑啉-6-磺酸盐）自由基阳离子（ABTS*+）和β-胡萝卜素-亚油酸酯模型系统（β-胡萝卜素）。结果发现，啤酒的抗氧化潜力与黄烷醇和黄酮类化合物密切相关，与总多酚的相关性稍低（R2值为0.8203至0.9393）。42名年龄在43-71岁之间、冠状动脉搭桥手术后患有高胆固醇血症的男性非饮酒志愿者被随机分为实验组（EG）和对照组（CG），每组21人。EG组的抗动脉粥样硬化饮食连续30天每天补充330毫升啤酒。短期饮用啤酒是否不仅会影响冠状动脉粥样硬化的危险因素，还会影响这一过程的标志物：血浆白蛋白及其抗氧化活性？为了实现这一目标，测定了总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、甘油三酯、血浆白蛋白和纤维蛋白原以及抗氧化活性。试验后，EG组患者的血浆脂质水平有显著改善，血浆抗氧化和抗凝活性增加。同时观察到血浆白蛋白浓度及其抗氧化活性平行增加。总之，基于饮料的生物活性，短期饮用啤酒对血浆脂质水平、血浆抗氧化和抗凝活性有积极影响。血浆白蛋白浓度及其抗氧化活性的增加可能是动脉粥样硬化状态的标志物。
