Iannazzo Daniela, Ettari Roberta, Giofrè Salvatore, Eid Ali H, Bitto Alessandra
Department of Engineering, University of Messina, 98166 Messina, Italy.
Department of Chemical, Biological, Pharmaceutical and Environmental Chemistry, University of Messina, 98165 Messina, Italy.
Cancers (Basel). 2020 Oct 27;12(11):3144. doi: 10.3390/cancers12113144.
Anticancer therapies cannot be included in a one-size-fits-all scenario; it is imperative to adapt therapies to the tumor molecular profile and most importantly to develop target-specific therapeutics. Nanotherapeutics can combine molecular imaging with molecular therapy in order to provide the maximum benefit to patients in terms of disease prevention, identification, and treatment. Nanotechnology applied to therapy provides numerous advantages in diagnostics and in drug delivery, especially for those malignant cells that are difficult to target or for drugs with poor bioavailability, such as those used for multiple myeloma (MM). This review summarizes the recent advances in the development of nanoparticle-based systems for the treatment of MM, taking into account the methods used for their functionalization, biocompatibility, and anticancer activity.
抗癌疗法不能一概而论；必须使疗法适应肿瘤分子特征，最重要的是开发针对特定靶点的治疗方法。纳米疗法可以将分子成像与分子治疗相结合，以便在疾病预防、识别和治疗方面为患者提供最大益处。应用于治疗的纳米技术在诊断和药物递送方面具有诸多优势，特别是对于那些难以靶向的恶性细胞或生物利用度差的药物，例如用于多发性骨髓瘤（MM）的药物。本综述总结了基于纳米颗粒的系统在治疗MM方面的最新进展，同时考虑了其功能化、生物相容性和抗癌活性所采用的方法。
