Xin Yanru, Yin Mingming, Zhao Liyuan, Meng Fanling, Luo Liang
College of Life Science and Technology, National Engineering Research Center for Nanomedicine, Huazhong University of Science and Technology, Wuhan 430074, China.
Cancer Biol Med. 2017 Aug;14(3):228-241. doi: 10.20892/j.issn.2095-3941.2017.0052.
The development of cancer nanotherapeutics has attracted great interest in the recent decade. Cancer nanotherapeutics have overcome several limitations of conventional therapies, such as nonspecific biodistribution, poor water solubility, and limited bioavailability. Nanoparticles with tuned size and surface characteristics are the key components of nanotherapeutics, and are designed to passively or actively deliver anti-cancer drugs to tumor cells. We provide an overview of nanoparticle-based drug delivery methods and cancer therapies based on tumor-targeting delivery strategies that have been developed in recent years.
在最近十年中，癌症纳米治疗学的发展引起了极大的关注。癌症纳米治疗学克服了传统疗法的若干局限性，如非特异性生物分布、水溶性差和生物利用度有限等问题。具有特定尺寸和表面特性的纳米颗粒是纳米治疗学的关键组成部分，其设计目的是将抗癌药物被动或主动地递送至肿瘤细胞。我们概述了近年来基于肿瘤靶向递送策略所开发的基于纳米颗粒的药物递送方法和癌症治疗方法。
