Katz R L, Keen C L, Litt I F, Hurley L S, Kellams-Harrison K M, Glader L J
Department of Pediatrics, Stanford University Medical Center, Davis.
J Adolesc Health Care. 1987 Sep;8(5):400-6. doi: 10.1016/0197-0070(87)90227-0.
Adolescents with anorexia nervosa were evaluated for clinical and biochemical evidence of zinc deficiency. To assess whether these patients would benefit from zinc supplementation, a double-blind, randomized, controlled trial was conducted. The mean zinc intake of the anorexic group calculated on the basis of three-day dietary records was 7.7 +/- 5.2 mg/day, which is significantly below the recommended daily allowance of 15 mg for adolescents (p less than 0.001). The mean urinary zinc excretion in the anorexic group was 257.1 +/- 212.7 micrograms/24 hours compared to 749.9 +/- 897.8 micrograms/24 hours in the control group (p less than 0.005). This result suggests that the zinc status of anorexia nervosa patients may be compromised due to an inadequate zinc intake. Zinc supplementation (50 mg elemental zinc/day) was followed by a decrease in the level of depression and anxiety as assessed by the Zung Depression Scale (p less than 0.05) and the State-Trait Anxiety Inventory (p less than 0.05), respectively. Our data suggest that individuals with anorexia nervosa may be at risk for zinc deficiency and may respond favorably after zinc supplementation.
对患有神经性厌食症的青少年进行了锌缺乏的临床和生化证据评估。为了评估这些患者是否能从补锌中获益，开展了一项双盲、随机、对照试验。根据三天饮食记录计算，厌食组的平均锌摄入量为7.7±5.2毫克/天，显著低于青少年每日推荐摄入量15毫克（p<0.001）。厌食组的平均尿锌排泄量为257.1±212.7微克/24小时，而对照组为749.9±897.8微克/24小时（p<0.005）。这一结果表明，神经性厌食症患者的锌状况可能因锌摄入不足而受到影响。补充锌（50毫克元素锌/天）后，通过zung抑郁量表评估的抑郁水平（p<0.05）和状态-特质焦虑量表评估的焦虑水平（p<0.05）均有所下降。我们的数据表明，神经性厌食症患者可能存在锌缺乏风险，补锌后可能会有良好反应。
