Department of Obstetrics, Gynecology and Reproductive Sciences, McGovern Medical School at The University of Texas Health Science Center at Houston (UTHealth), 6431 Fannin Street, MSB 3.264, Houston, TX 77030, USA.
Department of Obstetrics, Gynecology and Reproductive Sciences, McGovern Medical School at The University of Texas Health Science Center at Houston (UTHealth), 6431 Fannin Street, MSB 3.264, Houston, TX 77030, USA.
Obstet Gynecol Clin North Am. 2020 Dec;47(4):569-586. doi: 10.1016/j.ogc.2020.08.003. Epub 2020 Oct 7.
"Trials evaluating tocolytic use in preterm premature rupture of membranes (PPROM) have been small and lacked adequate power to evaluate uncommon outcomes. There still is much controversy on the benefit, length of use, route, and drug of choice among clinicians treating patients with PPROM. Most professional medical societies would propose to consider the use of tocolytics for 48 hours to allow for corticosteroid administration or to allow for maternal transfer to a higher level of care. Longer treatment regimens may lead to adverse maternal and perinatal outcomes. Insufficient data are available to make stronger and more definitive recommendations."
评估早产胎膜早破（PPROM）时使用保胎药物的试验规模较小，缺乏足够的能力来评估罕见结局。在治疗 PPROM 患者时，临床医生在获益、使用时长、途径和药物选择方面仍存在很大争议。大多数专业医学协会建议考虑使用保胎药物 48 小时，以便给予皮质激素治疗或让产妇转至更高一级的医疗中心。更长的治疗方案可能会导致产妇和围产儿不良结局。目前尚无足够的数据来提出更强有力和更明确的建议。
