Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA; Division of Hematology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Trends Mol Med. 2021 Apr;27(4):332-344. doi: 10.1016/j.molmed.2020.10.001. Epub 2020 Oct 26.
Acute myeloid leukemia (AML) is a cancer derived from the myeloid lineage of blood cells, characterized by overproduction of leukemic blasts. Although therapeutic improvements have made a significant impact on the outcomes of patients with AML, survival rates remain low due to a high incidence of relapse. Similar to how wildfires can reignite from hidden embers not extinguished from an initial round of firefighting, leukemic stem cells (LSCs) are the embers remaining after completion of traditional chemotherapeutic treatments. LSCs exhibit a unique metabolic profile and contain metabolically distinct subpopulations. In this review, we detail the metabolic features of LSCs and how thetse characteristics promote resistance to traditional chemotherapy. We also discuss new therapeutic approaches that target metabolic vulnerabilities of LSC to selectively eradicate them.
急性髓系白血病 (AML) 是一种起源于血细胞髓系的癌症，其特征是白血病细胞过度生成。尽管治疗方法的改进对 AML 患者的治疗效果产生了重大影响，但由于复发率高，生存率仍然较低。就像野火可以从第一轮消防扑灭后未熄灭的隐藏余烬中重新燃起一样，白血病干细胞 (LSC) 是在完成传统化疗后留下的余烬。LSC 表现出独特的代谢特征，并包含代谢上不同的亚群。在这篇综述中，我们详细描述了 LSC 的代谢特征，以及这些特征如何促进其对传统化疗的耐药性。我们还讨论了针对 LSC 代谢脆弱性的新治疗方法，以选择性地消灭它们。
