PET Center, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, 310003, Zhejiang, China.
Sino-German Tongji-Caritas Research Center of Ultrasound in Medicine, Department of Medical Ultrasound, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, China.
Cancer Lett. 2021 Jan 28;497:229-242. doi: 10.1016/j.canlet.2020.10.037. Epub 2020 Oct 27.
Sonodynamic therapy (SDT) represents a promising modality that provides the possibility of non-invasively eliminating solid tumors in a site-directed manner. In light of the complexity and heterogeneity of tumors, more and more studies are attempting to combine SDT with other therapeutic methods so as to achieve better tumor treatment effect, which sheds new light on the potential of SDT-based synergistic therapeutics. Herein, the representative studies of SDT-instructed multimodal synergistic cancer therapy are comprehensively presented, such as sono-chemotherapy, sono-radiotherapy, sono-immunotherapy, and sono-chemodynamic therapy, etc., and their incorporate mechanisms are discussed in detail. The current challenges and future prospects to promote the advanced development of SDT-based nanomedicines in this burgeoning research field are highlighted. It is believed that such an emerging synergistic therapeutic modality based on SDT will play a more significant role in the field of tumor precision treatment medicine.
声动力学疗法（SDT）是一种很有前途的治疗方式，它提供了一种非侵入性的、靶向消除实体肿瘤的可能性。鉴于肿瘤的复杂性和异质性，越来越多的研究试图将 SDT 与其他治疗方法相结合，以达到更好的肿瘤治疗效果，这为基于 SDT 的协同治疗的潜力带来了新的曙光。本文全面介绍了 SDT 指导的多模态协同癌症治疗的代表性研究，如声化疗、声放疗、声免疫治疗和声化学动力学治疗等，并详细讨论了它们的结合机制。本文还强调了当前推动这一新兴研究领域中基于 SDT 的纳米药物高级发展所面临的挑战和未来展望。相信这种基于 SDT 的新兴协同治疗方式将在肿瘤精准治疗医学领域发挥更重要的作用。
