Yi Shuanglong, Gao Yao, Yu Luodan, Chen Yu
Department of Radiology, Shanghai Institute of Thoracic Oncology, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Materdicine Lab, School of Life Sciences, Shanghai University, Shanghai, China.
Biomater Transl. 2025 Mar 25;6(1):24-39. doi: 10.12336/biomatertransl.2025.01.003. eCollection 2025.
Sonodynamic therapy (SDT) has emerged as a cutting-edge strategy for combating multidrug-resistant bacterial infections. Unlike conventional antibiotics, SDT leverages the generation of reactive oxygen species during the treatment process to inflict multifaceted damage on bacterial cells, thereby significantly reducing the likelihood of developing drug resistance. Compared to other physical sterilisation methods, such as ultraviolet irradiation, SDT offers enhanced tissue penetration, making it particularly suitable for addressing deep-seated infections, including osteomyelitis. Despite its significant advantages, the clinical translation of SDT for antibacterial applications faces several challenges. This review discusses the fundamental mechanisms of SDT, with a focus on phenomena such as cavitation-induced reactions and piezocatalytic generation of reactive oxygen species. Furthermore, it provides a comprehensive analysis of various sonosensitisers used in SDT, emphasising their potential to enhance therapeutic outcomes in areas such as infected wound healing, bone regeneration, and the mitigation of deep tissue inflammation. While SDT shows great promise in addressing multidrug-resistant bacterial infections, further research and development are essential to overcome existing limitations and unlock its full clinical potential.
声动力疗法（SDT）已成为对抗多重耐药细菌感染的前沿策略。与传统抗生素不同，SDT在治疗过程中利用活性氧的产生对细菌细胞造成多方面损害，从而显著降低产生耐药性的可能性。与其他物理灭菌方法（如紫外线照射）相比，SDT具有更强的组织穿透性，使其特别适合治疗包括骨髓炎在内的深部感染。尽管具有显著优势，但SDT在抗菌应用中的临床转化仍面临一些挑战。本综述讨论了SDT的基本机制，重点关注空化诱导反应和压电催化产生活性氧等现象。此外，它还对SDT中使用的各种声敏剂进行了全面分析，强调了它们在感染伤口愈合、骨再生和减轻深部组织炎症等领域提高治疗效果的潜力。虽然SDT在解决多重耐药细菌感染方面显示出巨大潜力，但进一步的研究和开发对于克服现有局限性并释放其全部临床潜力至关重要。
