Development. 2020 Oct 29;147(20):dev197293. doi: 10.1242/dev.197293.
Interacting morphogens produce periodic patterns in developing tissues. Such patterning can be modelled as reaction-diffusion (RD) processes (as originally formulated by Alan Turing), and although these models have been developed and refined over the years, they often tend to oversimplify biological complexity by restricting the number of interacting morphogens. A new paper in Development reports how perturbation analysis can guide multi-morphogen modelling of the striped patterning the roof of the mouse mouth. To hear more about the story, we caught up with first author Andrew Economou and his former supervisor Jeremy Green, Professor of Developmental Biology at King's College, London.
相互作用的形态发生素在发育组织中产生周期性模式。这种模式可以被建模为反应-扩散 (RD) 过程(最初由艾伦·图灵提出),尽管这些模型多年来得到了发展和完善,但它们往往通过限制相互作用的形态发生素的数量来过度简化生物复杂性。《发育》杂志上的一篇新论文报告了如何通过摄动分析来指导对老鼠口腔顶部条纹模式形成的多形态发生素建模。为了更多地了解这个故事,我们采访了第一作者安德鲁·伊科诺莫和他的前导师伦敦国王学院发育生物学教授杰里米·格林。