Department of Cardiology, Faculty of Medicine, İstanbul Medipol University; İstanbul-Turkey.
Anatol J Cardiol. 2020 Nov;24(5):309-315. doi: 10.14744/AnatolJCardiol.2020.78974.
Increased serum level of cystatin C, a sensitive biomarker for renal function, seems to predict adverse cardiovascular events. We investigated the predictive value of serum cystatin C for controlling hypertension in an observational study.
We screened 1037 adults residing in both rural and urban communities. They were grouped based on their diagnosis and control of hypertension.
Serum cystatin C levels in patients with uncontrolled hypertension were higher than those in patients with controlled hypertension (0.98±0.23 mg/L vs. 0.89±0.19 mg/L, p=0.001). However, serum creatinine levels were similar between these groups (0.72±0.20 mg/dL vs. 0.70±0.18 mg/dL, p=0.89). Serum cystatin C levels increased the probability of uncontrolled hypertension independent from confounding factors (odds ratio, 1.48; 95% confidence interval, 1.09-5.64; p=0.03).
Subtle kidney dysfunction may be detected using serum cystatin C concentrations among patients with poor blood pressure control and normal serum creatinine levels.
胱抑素 C 血清水平升高，这是肾功能的一个敏感生物标志物，似乎可以预测不良心血管事件。我们在一项观察性研究中研究了血清胱抑素 C 对控制高血压的预测价值。
我们筛选了居住在城乡社区的 1037 名成年人。他们根据高血压的诊断和控制情况进行分组。
未控制高血压患者的血清胱抑素 C 水平高于控制高血压患者（0.98±0.23mg/L 比 0.89±0.19mg/L，p=0.001）。然而，两组患者的血清肌酐水平相似（0.72±0.20mg/dL 比 0.70±0.18mg/dL，p=0.89）。血清胱抑素 C 水平升高独立于混杂因素增加了未控制高血压的可能性（比值比，1.48；95%置信区间，1.09-5.64；p=0.03）。
在血清肌酐水平正常但血压控制不佳的患者中，可能通过血清胱抑素 C 浓度检测到轻微的肾功能障碍。
