腹水液中的CA125、癌胚抗原（CEA）、CA19-9及异倍体细胞可能有助于诊断胃肠道和卵巢恶性肿瘤患者的腹膜癌转移。
CA125, CEA, CA19-9, and Heteroploid Cells in Ascites Fluid May Help Diagnose Peritoneal Carcinomatosis in Patients with Gastrointestinal and Ovarian Malignancies.
作者信息
Deng Lin, Guo Shikong, Li Hong, You Xianghui, Song Yang, Su Haichuan
机构信息
Department of Oncology, Tangdu Hospital, Air Force Military Medical University, Xi'an, Shaanxi, China.
Department of Orthopedics, Tangdu Hospital, Air Force Military Medical University, Xi'an, Shaanxi, China.
出版信息
Cancer Manag Res. 2020 Oct 22;12:10479-10489. doi: 10.2147/CMAR.S271596. eCollection 2020.
BACKGROUND
This study explored the value of ascites and serum CA125, CEA, and CA19-9 levels and ascites DNA ploidy analysis for the diagnosis of peritoneal carcinomatosis (PC) in patients with gastrointestinal and ovarian malignancies, which can cause ascites and may disseminate peritoneally.
METHODS
We measured ascites and serum levels of CA125, CEA, CA19-9 and performed an ascites DNA ploidy analysis in 58 patients with PC and 44 patients without PC.
RESULTS
We found that a high expression level of CA125 in ascites fluid was associated with the occurrence of PC in patients with gastrointestinal and ovarian malignancies (<0.001), and that high CEA and CA19- 9 levels in ascites fluid were associated with PC in patients with gastrointestinal malignancies (=0.001, =0.002). But, these tumor marker expression levels in ascites fluid were not significantly associated with the PC stage (>0.05). We found similar serum levels of CA125, CEA, and CA19-9 between patients with gastrointestinal and ovarian malignancies and PC and those without PC (>0.05). We found that the presence of three or more cells with heteroploid in the ascites samples was significantly associated with PC in gastrointestinal and ovarian malignancies (<0.001). In addition, the best ROC curves and highest AUCs were achieved by combining the CA125 level and heteroploid cell analysis results (AUC for gastrointestinal and ovarian malignancies, 0.815, AUC for gastrointestinal malignancies, 0.873). Moreover, the combined ascites CA125 level and result of heteroploid cell analysis provided the best diagnostic sensitivity and specificity for PC (75.9% and 79.5%, respectively, in gastrointestinal and ovarian malignancies; 85.0% and 86.7%, respectively, in gastrointestinal malignancies).
CONCLUSION
Ascites levels of CA125, CEA, CA19-9, and heteroploid cells can be considered valuable markers for the diagnosis of PC in patients with gastrointestinal and ovarian cancer.
背景
本研究探讨腹水及血清CA125、CEA和CA19-9水平以及腹水DNA倍体分析在胃肠道和卵巢恶性肿瘤患者腹膜癌（PC）诊断中的价值，这些恶性肿瘤可导致腹水并可能发生腹膜播散。
方法
我们检测了58例PC患者和44例非PC患者的腹水及血清CA125、CEA、CA19-9水平，并进行了腹水DNA倍体分析。
结果
我们发现，腹水中CA125高表达水平与胃肠道和卵巢恶性肿瘤患者PC的发生相关（<0.001），腹水中CEA和CA19-9高水平与胃肠道恶性肿瘤患者PC相关（=0.001，=0.002）。但是，腹水中这些肿瘤标志物表达水平与PC分期无显著相关性（>0.05）。我们发现胃肠道和卵巢恶性肿瘤合并PC患者与未合并PC患者的血清CA125、CEA和CA19-9水平相似（>0.05）。我们发现腹水中存在三个或更多异倍体细胞与胃肠道和卵巢恶性肿瘤患者的PC显著相关（<0.001）。此外，联合CA125水平和异倍体细胞分析结果可获得最佳ROC曲线和最高AUC（胃肠道和卵巢恶性肿瘤的AUC为0.815，胃肠道恶性肿瘤的AUC为0.873）。此外，联合腹水CA125水平和异倍体细胞分析结果对PC具有最佳诊断敏感性和特异性（胃肠道和卵巢恶性肿瘤分别为75.9%和79.5%；胃肠道恶性肿瘤分别为85.0%和86.7%）。
结论
腹水CA125、CEA、CA19-9水平及异倍体细胞可被视为胃肠道和卵巢癌患者PC诊断的有价值标志物。
Zotero 插件