Department of Biotechnology and Bioinformatics, School of Life Sciences, JSS Academy of Higher Education and Research, Mysuru, 570015, Karnataka, India.
Asian Pac J Cancer Prev. 2024 Oct 1;25(10):3413-3420. doi: 10.31557/APJCP.2024.25.10.3413.
Malignant ascites, a buildup of fluid in the abdominal cavity, is a serious consequence of many malignancies. This review aims to comprehend the biochemical makeup of malignant ascites, such as pH, cholesterol, protein, etc., which is crucial to developing therapeutics with better treatment outcomes and hence correlate with corresponding prognostic value. The unique tumour microenvironment exhibited by malignant ascites and the crosstalk between inflammatory cells, cytokines and chemokines, interactions between tumour and non-tumour cell types, activation of vital cell signalling pathways within the TME for VEGF-regulated sustained angiogenesis, cancer progression and metastasis is highlighted. This review addresses the need to develop comprehensive assay platforms to identify various biochemical aspects of ascites, to discover the interactions of the tumour microenvironment and to study VEGF-regulated permeability that can expedite early diagnosis and progression of ascites.
恶性腹水是许多恶性肿瘤的严重后果，即腹腔内积液的积聚。本综述旨在了解恶性腹水的生化成分，如 pH 值、胆固醇、蛋白质等，这对于开发具有更好治疗效果的治疗方法至关重要，因此与相应的预后价值相关。恶性腹水表现出独特的肿瘤微环境，炎症细胞、细胞因子和趋化因子之间的串扰，肿瘤和非肿瘤细胞类型之间的相互作用，TME 中关键细胞信号通路的激活，以实现 VEGF 调节的持续血管生成、癌症进展和转移，这一点得到了强调。本综述提出需要开发全面的分析平台来识别腹水的各种生化方面，以发现肿瘤微环境的相互作用，并研究 VEGF 调节的通透性，从而加速腹水的早期诊断和进展。
