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皮肌炎:一例乳腺癌患者的首发临床病例

Dermatomyositis: A Presenting Clinical Vignette in a Patient With Breast Cancer.

作者信息

Allouch Ali, Zaatarikahale Teisir B, Moussa Mohamad K, Jounblat Youssef, Bitar Nizar

机构信息

Oncology, Lebanese University, Faculty of Medical Sciences, Beirut, LBN.

Internal Medicine, Lebanese University, Faculty of Medical Sciences, Beirut, LBN.

出版信息

Cureus. 2020 Sep 23;12(9):e10624. doi: 10.7759/cureus.10624.

DOI:10.7759/cureus.10624
PMID:33123437
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7584289/
Abstract

Dermatomyositis (DM) is a rare idiopathic inflammatory myopathy, which is associated with malignancy in 15%-30% of cases. Breast cancer, the most frequent malignancy diagnosed in women, can feature uncommon presentations, such as paraneoplastic syndrome including DM. The aim of this case is to promote awareness regarding any adult patient who presents with DM for early detection and treatment of a possible underlying malignancy. Our patient was diagnosed and treated for DM without any improvement, until she presented to our department, and after a comprehensive history and physical exam, an underlying breast cancer was detected. It was metastatic unfortunately, but she improved after treatment with regression of symptoms related to DM.

摘要

皮肌炎(DM)是一种罕见的特发性炎性肌病,15% - 30%的病例与恶性肿瘤相关。乳腺癌是女性中最常诊断出的恶性肿瘤,可能有不常见的表现,如包括皮肌炎在内的副肿瘤综合征。本病例的目的是提高对任何出现皮肌炎的成年患者的认识,以便早期发现和治疗可能潜在的恶性肿瘤。我们的患者被诊断为皮肌炎并接受了治疗,但没有任何改善,直到她来到我们科室,经过全面的病史询问和体格检查后,发现了潜在的乳腺癌。不幸的是,已经发生转移,但她在接受治疗后症状有所改善,与皮肌炎相关的症状出现了消退。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b07/7584289/fed4a325cb31/cureus-0012-00000010624-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b07/7584289/b34f169c9f17/cureus-0012-00000010624-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b07/7584289/8cf5040a9ead/cureus-0012-00000010624-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b07/7584289/9b02f8fef39c/cureus-0012-00000010624-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b07/7584289/fed4a325cb31/cureus-0012-00000010624-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b07/7584289/b34f169c9f17/cureus-0012-00000010624-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b07/7584289/8cf5040a9ead/cureus-0012-00000010624-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b07/7584289/9b02f8fef39c/cureus-0012-00000010624-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b07/7584289/fed4a325cb31/cureus-0012-00000010624-i04.jpg

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本文引用的文献

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Breast cancer and dermatomyositis: a case study and literature review.乳腺癌与皮肌炎:一项病例研究及文献综述
Curr Oncol. 2017 Oct;24(5):e429-e433. doi: 10.3747/co.24.3696. Epub 2017 Oct 25.
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Global Cancer in Women: Burden and Trends.全球女性癌症:负担与趋势
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Polymyositis and dermatomyositis as a risk of developing cancer.多发性肌炎和皮肌炎与患癌风险。
Reumatologia. 2015;53(2):101-5. doi: 10.5114/reum.2015.51510. Epub 2015 May 18.
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Dermatomyositis presenting as a paraneoplastic syndrome with resolution of symptoms following surgical management of underlying breast malignancy.皮肌炎表现为副肿瘤综合征,在对潜在的乳腺恶性肿瘤进行手术治疗后症状得以缓解。
J Surg Case Rep. 2015 Jul 7;2015(7):rjv075. doi: 10.1093/jscr/rjv075.
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A rare case of severe myositis as paraneoplastic syndrome on breast cancer.一例罕见的以严重肌炎为副肿瘤综合征的乳腺癌病例。
World J Surg Oncol. 2015 Apr 1;13:134. doi: 10.1186/s12957-015-0534-5.
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Cancer risk in dermatomyositis: a meta-analysis of cohort studies.皮肌炎患者的癌症风险:队列研究的荟萃分析
Am J Clin Dermatol. 2015 Apr;16(2):89-98. doi: 10.1007/s40257-015-0120-1.
7
Genome-wide association study of dermatomyositis reveals genetic overlap with other autoimmune disorders.皮肌炎的全基因组关联研究揭示了与其他自身免疫性疾病的遗传重叠。
Arthritis Rheum. 2013 Dec;65(12):3239-47. doi: 10.1002/art.38137.
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Clinical features of inflammatory myopathies and their association with malignancy: a systematic review in asian population.炎性肌病的临床特征及其与恶性肿瘤的关联:亚洲人群的系统评价
ISRN Rheumatol. 2013;2013:509354. doi: 10.1155/2013/509354. Epub 2013 Feb 25.
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Dermatomyositis presenting as a paraneoplastic syndrome due to underlying breast cancer.皮肌炎作为潜在乳腺癌所致的副肿瘤综合征出现。
BMJ Case Rep. 2011 Feb 2;2011:bcr1020103416. doi: 10.1136/bcr.10.2010.3416.
10
Flare-up of dermatomyositis along with recurrence of breast cancer.皮肌炎发作伴乳腺癌复发。
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