Yamamoto E, Iwanaga M
Department of Otolaryngology, Faculty of Medicine, Kyoto University, Japan.
J Laryngol Otol. 1987 Sep;101(9):897-904. doi: 10.1017/s0022215100102944.
Soft-tissue reaction to ceramic ossicular replacement prostheses (CORP) has been evaluated histologically in rabbits and humans. One week after implantation, severe inflammatory and foreign body reaction was observed in the fibrous connective tissue surrounding the prosthesis. Though some inflammatory response was seen after one month, after three months the CORP was surrounded by a layer of fibrous connective tissue without any foreign body giant cell, histiocyte or inflammatory cell infiltration. Our satisfactory clinical results in humans without placing a cartilage between the CORP and the fascia graft may be due to the excellent soft-tissue compatibility of CORP, as demonstrated in this study.
已通过组织学方法对陶瓷听小骨置换假体（CORP）在兔子和人类体内的软组织反应进行了评估。植入一周后，在假体周围的纤维结缔组织中观察到严重的炎症和异物反应。虽然一个月后仍可见一些炎症反应，但三个月后，CORP被一层纤维结缔组织所包围，没有任何异物巨细胞、组织细胞或炎症细胞浸润。在本研究中已证明，我们在人类患者中未在CORP与筋膜移植物之间放置软骨却取得了令人满意的临床结果，这可能归因于CORP出色的软组织相容性。
