Griss P, Werner E, Buchinger R, Büsing C M, Heimke G
Arch Orthop Unfallchir. 1977 Nov 21;90(1):29-40. doi: 10.1007/BF00415892.
This investigation presents experimental results on possible non-specific foreign body sarcoma induction by Al2O3-ceramic implants. Solid and porous discs, subcutaneously implanted in rats produce a sarcoma rate of 17.4 resp. 17.8 p.c. while roughly perforated discs initiate sarcomas at a rate of 25.4 p.c. These values were found to be lower than comparative values in the literature produced with different metals and medical grade plastics. Powdered alumina implants did not produce any sarcomas. Only this latter result can mainly be transferred into prognostic assumptions concerning the clinical application of Al2O3-ceramic. The results are discussed extensively in the lights of the existing literature, this indicating that the tested ceramic itself may not possess a significant sarcogenetic potency in humans.
本研究展示了关于Al2O3陶瓷植入物可能诱导非特异性异物肉瘤的实验结果。皮下植入大鼠体内的实心和多孔圆盘产生肉瘤的比率分别为17.4%和17.8%，而大致穿孔的圆盘引发肉瘤的比率为25.4%。这些数值低于文献中使用不同金属和医用级塑料得出的对比值。粉末状氧化铝植入物未产生任何肉瘤。只有后一个结果可主要转化为关于Al2O3陶瓷临床应用的预后假设。结合现有文献对结果进行了广泛讨论，这表明所测试的陶瓷本身在人体中可能不具有显著的致肉瘤能力。
