Martín-González Javier, Montero-Bullón Javier-Fernando, Lacal Jesus
Molecular Genetics of Human Diseases Group, Department of Microbiology and Genetics, Faculty of Biology, University of Salamanca, Campus Miguel de Unamuno, Salamanca, E-37007, Spain.
Metabolic Engineering Group, Department of Microbiology and Genetics, University of Salamanca, Campus Miguel de Unamuno, Salamanca, E-37007, Spain.
Microb Biotechnol. 2021 Jan;14(1):111-125. doi: 10.1111/1751-7915.13692. Epub 2020 Oct 30.
Dictyostelium discoideum is one of eight non-mammalian model organisms recognized by the National Institute of Health for the study of human pathology. The use of this slime mould is possible owing to similarities in cell structure, behaviour and intracellular signalling with mammalian cells. Its haploid set of chromosomes completely sequenced amenable to genetic manipulation, its unique and short life cycle with unicellular and multicellular stages, and phenotypic richness encoding many human orthologues, make Dictyostelium a representative and simple model organism to unveil cellular processes in human disease. Dictyostelium studies within the biomedical field have provided fundamental knowledge in the areas of bacterial infection, immune cell chemotaxis, autophagy/phagocytosis and mitochondrial and neurological disorders. Consequently, Dictyostelium has been used to the development of related pharmacological treatments. Herein, we review the utilization of Dictyostelium as a model organism in biomedicine.
盘基网柄菌是美国国立卫生研究院认可的用于研究人类病理学的八种非哺乳动物模式生物之一。由于其细胞结构、行为和细胞内信号传导与哺乳动物细胞相似，因此可以使用这种黏菌。它的单倍体染色体组已完全测序，易于进行基因操作，其独特而短暂的生命周期包括单细胞和多细胞阶段，以及编码许多人类直系同源基因的丰富表型，使盘基网柄菌成为揭示人类疾病细胞过程的代表性和简单模式生物。在生物医学领域对盘基网柄菌的研究已经在细菌感染、免疫细胞趋化性、自噬/吞噬作用以及线粒体和神经疾病等方面提供了基础知识。因此，盘基网柄菌已被用于相关药物治疗的开发。在此，我们综述了盘基网柄菌作为生物医学模式生物的应用。
