Coope J
Medical Centre, Bollington, Macclesfield, Cheshire, UK.
J Hypertens Suppl. 1987 Aug;5(3):S69-72.
Hypertension is a common finding in patients aged over 60 years, but the following questions need answering. How dangerous is it? Will lowering the blood pressure reduce the attendant risks? What is the 'cost' of such treatment in terms of side effects, drug-induced disease and health service finance? Two recently completed trials throw light on these problems: EWPHE (European Working Party on Hypertension in the Elderly), a European study based on hospital-clinic attenders, using a diuretic backed up with methyldopa; and HEP (randomized trial of treatment of Hypertension in Elderly Patients in Primary Care), based on general-practice screening in England and Wales using atenolol and bendrofluazide. The results of these trials were compared and the findings were broadly similar in the two studies. Some of the differences may be due to the different selection of patients. It is concluded that elderly patients with sustained blood pressures greater or equal to 170/90 mmHg would benefit from treatment by substantial reduction of stroke. Diuretics or beta-blockers, alone or together, are acceptable treatments in elderly subjects.
高血压在60岁以上的患者中很常见,但以下问题需要解答。它有多危险?降低血压是否会降低相关风险?就副作用、药物引起的疾病和医疗服务费用而言,这种治疗的“成本”是多少?最近完成的两项试验为这些问题提供了线索:EWPHE(欧洲老年高血压工作组),一项基于医院门诊患者的欧洲研究,使用利尿剂并辅以甲基多巴;以及HEP(老年患者高血压初级保健治疗随机试验),基于英格兰和威尔士的全科筛查,使用阿替洛尔和苄氟噻嗪。对这些试验的结果进行了比较,两项研究的结果大致相似。一些差异可能是由于患者选择不同。得出的结论是,血压持续高于或等于170/90 mmHg的老年患者通过大幅降低中风风险将从治疗中获益。利尿剂或β受体阻滞剂单独或联合使用,都是老年患者可接受的治疗方法。