Cyrus Tang Hematology Center, Collaborative Innovation Center of Hematology, State Key Laboratory of Radiation Medicine and Prevention, Soochow University, Suzhou, China.
MOH Key Laboratory of Thrombosis and Hemostasis, Jiangsu Institute of Hematology, the First Affiliated Hospital of Soochow University, Suzhou, China.
Biochem Soc Trans. 2020 Oct 30;48(5):1905-1916. doi: 10.1042/BST20190760.
Atrial natriuretic peptide (ANP) is of major importance in the maintenance of electrolyte balance and normal blood pressure. Reduced plasma ANP levels are associated with the increased risk of cardiovascular disease. Corin is a type II transmembrane serine protease that converts the ANP precursor to mature ANP. Corin deficiency prevents ANP generation and alters electrolyte and body fluid homeostasis. Corin is synthesized as a zymogen that is proteolytically activated on the cell surface. Factors that disrupt corin folding, intracellular trafficking, cell surface expression, and zymogen activation are expected to impair corin function. To date, CORIN variants that reduce corin activity have been identified in hypertensive patients. In addition to the heart, corin expression has been detected in non-cardiac tissues, where corin and ANP participate in diverse physiological processes. In this review, we summarize the current knowledge in corin biosynthesis and post-translational modifications. We also discuss tissue-specific corin expression and function in physiology and disease.
心钠肽（ANP）在维持电解质平衡和正常血压方面具有重要意义。血浆 ANP 水平降低与心血管疾病风险增加有关。心钠肽酶（Corin）是一种 II 型跨膜丝氨酸蛋白酶，可将 ANP 前体转化为成熟的 ANP。Corin 缺乏会阻止 ANP 的生成，并改变电解质和体液的动态平衡。Corin 作为酶原合成，在细胞表面经蛋白水解激活。预计会破坏 Corin 功能的因素包括 Corin 折叠、细胞内运输、细胞表面表达和酶原激活。迄今为止，在高血压患者中已经发现了降低 Corin 活性的 CORIN 变体。除了心脏，Corin 在非心脏组织中也有表达，在这些组织中 Corin 和 ANP 参与了多种生理过程。在这篇综述中，我们总结了 Corin 生物合成和翻译后修饰的最新知识。我们还讨论了 Corin 在生理和疾病中的组织特异性表达和功能。
