治疗大使计划：一种高度可接受和可行的基于社区的同伴干预措施，针对南非艾滋病毒感染者中延迟或停止抗逆转录病毒治疗的人群。

The Treatment Ambassador Program: A Highly Acceptable and Feasible Community-Based Peer Intervention for South Africans Living with HIV Who Delay or Discontinue Antiretroviral Therapy.

机构信息

Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.

Harvard Medical School, Boston, MA, USA.

出版信息

AIDS Behav. 2021 Apr;25(4):1129-1143. doi: 10.1007/s10461-020-03063-1. Epub 2020 Oct 30.

DOI:10.1007/s10461-020-03063-1

PMID:33125587

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7979476/

Abstract

We conducted a novel pilot randomized controlled trial of the Treatment Ambassador Program (TAP), an 8-session, peer-based, behavioral intervention for people with HIV (PWH) in South Africa not on antiretroviral therapy (ART). PWH (43 intervention, 41 controls) completed baseline, 3- and 6-month assessments. TAP was highly feasible (90% completion), with peer counselors demonstrating good intervention fidelity. Post-intervention interviews showed high acceptability of TAP and counselors, who supported autonomy, assisted with clinical navigation, and provided psychosocial support. Intention-to-treat analyses indicated increased ART initiation by 3 months in the intervention vs. control arm (12.2% [5/41] vs. 2.3% [1/43], Fisher exact p-value = 0.105; Cohen's h = 0.41). Among those previously on ART (off for > 6 months), 33.3% initiated ART by 3 months in the intervention vs. 14.3% in the control arm (Cohen's h = 0.45). Results suggest that TAP was highly acceptable and feasible among PWH not on ART.

摘要

我们开展了一项新的试点随机对照试验，研究了治疗大使计划（TAP），这是一种针对南非未接受抗逆转录病毒治疗（ART）的艾滋病毒感染者（PWH）的 8 节基于同伴的行为干预措施。PWH（43 名干预组，41 名对照组）完成了基线、3 个月和 6 个月的评估。TAP 具有很高的可行性（完成率为 90%），同伴顾问表现出良好的干预一致性。干预后的访谈表明，TAP 和顾问的接受度很高，他们支持自主性，协助临床导航，并提供心理社会支持。意向治疗分析表明，干预组在 3 个月时开始接受 ART 的比例高于对照组（12.2%[5/41]比 2.3%[1/43]，Fisher 精确检验 p 值=0.105；Cohen's h=0.41）。在那些之前接受过 ART（停药超过 6 个月）的人中，干预组有 33.3%在 3 个月时开始接受 ART，而对照组为 14.3%（Cohen's h=0.45）。结果表明，TAP 在未接受 ART 的 PWH 中具有很高的可接受性和可行性。