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当肠道菌群潜入脂肪时,脂肪也会卷土重来。

When Gut Microbiota Creep into Fat, the Fat Creeps Back.

机构信息

Division of Gastroenterology and Hepatology, Stanford School of Medicine, Stanford, CA, USA; Microbiology & Immunology, Stanford School of Medicine, Stanford, CA, USA.

Microbiology & Immunology, Stanford School of Medicine, Stanford, CA, USA; Center for Human Microbiome Studies, Stanford School of Medicine, Stanford, CA, USA.

出版信息

Cell. 2020 Oct 29;183(3):589-591. doi: 10.1016/j.cell.2020.10.008.

DOI:10.1016/j.cell.2020.10.008
PMID:33125887
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8101628/
Abstract

Ha and colleagues describe a previously unappreciated diversity of microbes in the mesenteric adipose tissue (MAT) surrounding the GI tract. Viable bacteria that are mislocalized from the gut microbiota and metabolically adapted to the MAT contribute to the "creeping fat" of Crohn's disease.

摘要

哈及其同事描述了胃肠道周围肠系膜脂肪组织(MAT)中以前未被重视的微生物多样性。从肠道微生物群错位定位并适应 MAT 代谢的存活细菌导致了克罗恩病的“ creeping fat”。

相似文献

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When Gut Microbiota Creep into Fat, the Fat Creeps Back.当肠道菌群潜入脂肪时,脂肪也会卷土重来。
Cell. 2020 Oct 29;183(3):589-591. doi: 10.1016/j.cell.2020.10.008.
2
Creeping Fat in Crohn's Disease: Innocuous or innocuum?克罗恩病中的 creeping fat:无害还是无害?
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4
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引用本文的文献

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World J Gastroenterol. 2024 Nov 7;30(41):4514-4517. doi: 10.3748/wjg.v30.i41.4514.
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World J Clin Cases. 2022 Nov 6;10(31):11240-11251. doi: 10.12998/wjcc.v10.i31.11240.
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World J Gastroenterol. 2022 Aug 7;28(29):3838-3853. doi: 10.3748/wjg.v28.i29.3838.
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The development and structure of the mesentery.肠系膜的发生和结构。
Commun Biol. 2021 Aug 18;4(1):982. doi: 10.1038/s42003-021-02496-1.
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Contribution of Adipose Tissue to the Chronic Immune Activation and Inflammation Associated With HIV Infection and Its Treatment.脂肪组织对与 HIV 感染及其治疗相关的慢性免疫激活和炎症的贡献。
Front Immunol. 2021 Jun 18;12:670566. doi: 10.3389/fimmu.2021.670566. eCollection 2021.

本文引用的文献

1
Translocation of Viable Gut Microbiota to Mesenteric Adipose Drives Formation of Creeping Fat in Humans.肠道共生菌易位至肠系膜脂肪促进人类“爬行脂肪”的形成。
Cell. 2020 Oct 29;183(3):666-683.e17. doi: 10.1016/j.cell.2020.09.009. Epub 2020 Sep 28.
2
Adipose Tissue Distribution, Inflammation and Its Metabolic Consequences, Including Diabetes and Cardiovascular Disease.脂肪组织分布、炎症及其代谢后果,包括糖尿病和心血管疾病。
Front Cardiovasc Med. 2020 Feb 25;7:22. doi: 10.3389/fcvm.2020.00022. eCollection 2020.
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The gut microbiome and metabolic syndrome.肠道微生物组与代谢综合征。
J Clin Invest. 2019 Oct 1;129(10):4050-4057. doi: 10.1172/JCI129194.
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The mesentery: structure, function, and role in disease.肠系膜:结构、功能及其在疾病中的作用。
Lancet Gastroenterol Hepatol. 2016 Nov;1(3):238-247. doi: 10.1016/S2468-1253(16)30026-7. Epub 2016 Oct 12.
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Inflammation, metaflammation and immunometabolic disorders.炎症、代谢性炎症和免疫代谢紊乱。
Nature. 2017 Feb 8;542(7640):177-185. doi: 10.1038/nature21363.
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Roles for Intestinal Bacteria, Viruses, and Fungi in Pathogenesis of Inflammatory Bowel Diseases and Therapeutic Approaches.肠道细菌、病毒和真菌在炎症性肠病发病机制中的作用及治疗方法
Gastroenterology. 2017 Feb;152(2):327-339.e4. doi: 10.1053/j.gastro.2016.10.012. Epub 2016 Oct 18.
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Bacterial translocation - impact on the adipocyte compartment.细菌易位——对脂肪细胞区室的影响。
Front Immunol. 2014 Jan 6;4:510. doi: 10.3389/fimmu.2013.00510.
8
Mesenteric fat as a source of C reactive protein and as a target for bacterial translocation in Crohn's disease.肠系膜脂肪作为 C 反应蛋白的来源和克罗恩病细菌易位的靶点。
Gut. 2012 Jan;61(1):78-85. doi: 10.1136/gutjnl-2011-300370. Epub 2011 Sep 21.
9
Landmark article Oct 15, 1932. Regional ileitis. A pathological and clinical entity. By Burril B. Crohn, Leon Ginzburg, and Gordon D. Oppenheimer.里程碑式文章 1932 年 10 月 15 日。局限性肠炎。一种病理和临床实体。作者:伯里尔·B·克罗恩、利昂·金兹伯格和戈登·D·奥本海默。
JAMA. 1984 Jan 6;251(1):73-9. doi: 10.1001/jama.251.1.73.
10
[Bacterial translocation in Crohn disease].[克罗恩病中的细菌易位]
Gastroenterol Clin Biol. 1992;16(10):777-81.