碳酸酐酶 9 表达与鼻窦鳞状细胞癌不良预后的关系。
Association between carbonic anhydrase 9 expression and poor prognosis in sinonasal squamous cell carcinoma.
机构信息
Department of Clinical Pathology, Eye & ENT Hospital, Fudan University, Shanghai, China.
Department of Otolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, China.
出版信息
Ann Diagn Pathol. 2020 Dec;49:151643. doi: 10.1016/j.anndiagpath.2020.151643. Epub 2020 Oct 17.
OBJECTIVES
Carbonic anhydrase 9 (CA9), as a member of the carbonic anhydrase enzyme family, was an endogenous marker of hypoxia. Previous studies suggested CA9 expression was correlated with poor prognosis in multiple types of malignancies. Therefore, this study was to evaluate the role of CA9 in sinonasal squamous cell carcinoma (SNSCC) and to determine whether this biomarker was associated with patient clinicopathologic characteristics and prognosis.
METHODS
We assessed 63 patients diagnosed with SNSCC in 2013-2017 who underwent curative surgery. Tumor specimens was immunohistochemically analyzed for CA9 expression. The expression levels of CA9 was evaluated in relation to clinicopathological factors and prognosis.
RESULTS
Positive expression of CA9 was observed in 21 (33.3%) patients and was significantly correlated with local recurrence (p = 0.016), overall survival (OS) (p = 0.003) and disease-free survival (DFS) (p = 0.002). In Cox's multivariate analysis, CA9 expression was an independent negative prognostic factor for OS (p = 0.048) and DFS (p = 0.019).
CONCLUSIONS
Our findings demonstrated that CA9 overexpression could be used as an independent prognostic biomarker and therapeutic target in SNSCC.
目的
碳酸酐酶 9（CA9）作为碳酸酐酶酶家族的一员，是缺氧的内源性标志物。先前的研究表明，CA9 的表达与多种恶性肿瘤的不良预后相关。因此，本研究旨在评估 CA9 在鼻腔鼻窦鳞状细胞癌（SNSCC）中的作用，并确定该生物标志物是否与患者的临床病理特征和预后相关。
方法
我们评估了 2013-2017 年间接受根治性手术的 63 例 SNSCC 患者。采用免疫组织化学方法分析肿瘤标本中 CA9 的表达。评估 CA9 的表达水平与临床病理因素和预后的关系。
结果
21 例（33.3%）患者的 CA9 表达阳性，与局部复发（p=0.016）、总生存（OS）（p=0.003）和无病生存（DFS）（p=0.002）显著相关。在 Cox 多因素分析中，CA9 表达是 OS（p=0.048）和 DFS（p=0.019）的独立预后不良因素。
结论
我们的研究结果表明，CA9 过表达可以作为 SNSCC 的独立预后生物标志物和治疗靶点。
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