Evans Gethin H, McLaughlin John, Yau Adora M W
School of Healthcare Science, Manchester Metropolitan University, Manchester, United Kingdom.
Division of Diabetes, Endocrinology and Gastroenterology, School of Medical Sciences, University of Manchester and Salford Royal Hospitals, Manchester, United Kingdom.
Front Nutr. 2018 Oct 10;5:94. doi: 10.3389/fnut.2018.00094. eCollection 2018.
The ingestion of fructose is of interest due to previously reported differences in gastrointestinal, appetite, and metabolic effects when compared to glucose ingestion when ingested in liquid solution. The aim of this study was to examine these variables when fructose and glucose are added to a semi-solid meal. Seven healthy male participants completed three experimental trials involving the ingestion of 300 mL of semi-skimmed milk mixed with 40 g of instant porridge mix (CON) and with the addition of either 40 g of glucose (GLU) or fructose (FRU). Subjective feelings of appetite were assessed for 2 h after ingestion with blood samples collected at regular intervals. Gastric emptying rate was assessed using the C breath test method. Half emptying time was not different between trials (CON = 159 ± 51 min; GLU = 197 ± 46 min; FRU = 198 ± 67 min: = 0.117). No differences were observed for any subjective measurements of appetite ( > 0.05) while blood glucose was elevated ( < 0.05) 20 min after ingestion on both GLU and FRU with this tending to be higher on GLU than FRU. FRU resulted in greater ( < 0.05) blood lactate concentrations than on the other trials. The results of this study demonstrate that gastric emptying rate of glucose and fructose is similar when ingested in a semi-solid meal. In addition, there is little difference in appetite response between these sugars, however, there are some differences in metabolic response which deserve further study.
由于先前报道，与液体溶液中摄入葡萄糖相比，摄入果糖在胃肠道、食欲和代谢影响方面存在差异，因此果糖的摄入备受关注。本研究的目的是在半固体餐中添加果糖和葡萄糖时，检测这些变量。七名健康男性参与者完成了三项实验试验，包括摄入300毫升半脱脂牛奶与40克即食粥粉混合（对照组），以及添加40克葡萄糖（葡萄糖组）或果糖（果糖组）。摄入后2小时评估主观食欲感受，并定期采集血样。使用C呼气试验法评估胃排空率。各试验间的半排空时间无差异（对照组 = 159 ± 51分钟；葡萄糖组 = 197 ± 46分钟；果糖组 = 198 ± 67分钟：P = 0.117）。食欲的任何主观测量指标均未观察到差异（P > 0.05），而在葡萄糖组和果糖组摄入后20分钟时血糖升高（P < 0.05），且葡萄糖组往往高于果糖组。果糖组的血乳酸浓度高于其他试验组（P < 0.05）。本研究结果表明，在半固体餐中摄入时，葡萄糖和果糖的胃排空率相似。此外，这些糖类之间的食欲反应差异不大，然而，代谢反应存在一些差异，值得进一步研究。
